Nardilysin Explained
| Nardilysin |
| Ec Number: | 3.4.24.61 |
| Cas Number: | 292850-69-2 |
Nardilysin (N-arginine dibasic convertase, NRD-convertase) is an enzyme.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction
Hydrolysis of polypeptides, preferably at -Xaa-Arg-Lys-, and less commonly at -Arg-Arg-Xaa-, in which Xaa is not Arg or Lys
This enzyme is present rat brain and testis.
Notes and References
- Gomez S, Gluschankof P, Morel A, Cohen P . The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes . The Journal of Biological Chemistry . 260 . 19 . 10541–5 . September 1985 . 10.1016/S0021-9258(19)85118-9 . 3897221 . free .
- Gluschankof P, Gomez S, Morel A, Cohen P . Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex . The Journal of Biological Chemistry . 262 . 20 . 9615–20 . July 1987 . 10.1016/S0021-9258(18)47978-1 . 2885328 . free .
- Chesneau V, Pierotti AR, Barré N, Créminon C, Tougard C, Cohen P . Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues . The Journal of Biological Chemistry . 269 . 3 . 2056–61 . January 1994 . 10.1016/S0021-9258(17)42134-X . 8294457 . free .
- Pierotti AR, Prat A, Chesneau V, Gaudoux F, Leseney AM, Foulon T, Cohen P . N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes . Proceedings of the National Academy of Sciences of the United States of America . 91 . 13 . 6078–82 . June 1994 . 8016118 . 44141 . 10.1073/pnas.91.13.6078 . 1994PNAS...91.6078P . free .
