Nanos 3′ UTR translation control element explained

Nanos 3′ UTR translation control element
Symbol:nos_TCE
Rfam:RF00161
Rna Type:Cis-reg
Tax Domain:Eukaryota

Nanos 3′ UTR translation control element is a cis-regulatory element in the 3′ untranslated region (3′ UTR) of the messenger RNA which encodes the Nanos protein. The Nanos protein in Drosophila is required for correct morphogenesis (anterior/posterior patterning) in the Drosophila embryo. Translation of the Nanos mRNA is repressed in the bulk cytoplasm and activated in the posterior region. The translation control element (TCE) in the 3'UTR forms a Y-shaped secondary structure, part of which is recognised by the Smaug protein and leads to translational repression.[1]

Notes and References

  1. Crucs S, Chatterjee S, Gavis ER . Overlapping but distinct RNA elements control repression and activation of nanos translation . Mol. Cell . 5 . 3 . 457–467 . 2000 . 10882131 . 10.1016/S1097-2765(00)80440-2 . free .