Naltriben Explained

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]

See also

Notes and References

  1. Sofuoglu M, Portoghese PS, Takemori AE . Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes . The Journal of Pharmacology and Experimental Therapeutics . 257 . 2 . 676–80 . May 1991 . 1851833 .
  2. Stewart PE, Holper EM, Hammond DL . Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes . Life Sciences . 1994 . 55 . 4 . PL79-84 . 8028443 . 10.1016/0024-3205(94)00738-1 .

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