Naloxonazine Explained

Naloxonazine is a potent, irreversible μ-opioid receptor antagonist.^[1] Naloxonazine forms spontaneously in acidic solutions of naloxazone, and may be responsible for much or all of the irreversible μ opioid receptor binding displayed by the latter.^[2]

See also

• Oxymorphone-3-methoxynaltrexonazine, a similar opioid also having two complete and mirrored morphinan carbon skeletons

Notes and References

1. http://www.tocris.com/dispprod.php?ItemId=1677 Naloxonazine dihydrochloride
2. Hahn . E. F. . Pasternak, G. W. . Naloxonazine, a potent, long-lasting inhibitor of opiate binding sites . . 31 . 12–13 . 1385–1388 . September 1982 . 10.1016/0024-3205(82)90387-3 . 6292633 .