Naim Akhtar Khan Explained

Naim Akhtar Khan
Birth Date:30 June 1959
Birth Place:India
Nationality:French
Fields:Physiology
Work Institutions:University of Burgundy
Known For:Research on fat taste receptors and obesity

Naim Akhtar Khan (born June 30, 1959, in India) is a French physiologist and professor at the University of Burgundy, Dijon, France. He leads the research team, Nutrition Physiology & Toxicology (NUTox).[1] [2] [3] [4]

Biography

Khan obtained his Master's degree in 1979 and completed his PhD at the age of 24. He conducted postdoctoral research at the AIIMS and AMU in India. After a brief research stint in 1987 at the Institut Für Immunologie, Munich, Germany, he moved to Mexico for a postdoctoral fellowship in NeuroImmunology at the National Institute for Neurology and Neurosurgery. In 1988, he relocated to Rennes, France, for a second doctorate in NeuroOncology, focusing on the transmembrane transport of polyamines.[5] Khan was awarded his authorization to direct research (HDR) in 1995 and became a university professor in Dijon in 1997.

Career

Khan began his teaching career in 1993 as a lecturer in Limoges, France, working on "Fundamental and Comparative Immunology." In 2003, he was appointed as director of the Department of Physiology, Immunology, and Neurosciences at the University of Burgundy. His research led to the publication of significant results in 2014 on the characterization of fat taste receptors, contributing to the development of chemical compounds that mimic fat taste, reducing food intake in obese subjects. These compounds target the CD36 and GPR120 receptors on the tongue.[6] [7]

In 2019, Khan filed two European patents in the Innovation category.[8] [9] In 2021, he co-founded the company "EktaH",[10] [11] focusing on developing new therapeutic solutions to combat obesity.[12] [13] In 2022, he joined the Outreach and Engagement Committee of the International Scientific Council,[14] and in 2023, he was appointed a Fellow of the Academy of the IUPS.[15] [16]

Research

Naim Khan's research team, NUTox, has made contributions to understanding the physiological mechanisms of fat taste perception, particularly in relation to obesity. The cornerstone of their research is the concept that while lifestyle modifications such as a low-calorie diet or increased physical activity are traditional interventions for obesity, they often fail in the long term due to humans' genetic, cultural, or socio-economic preference for fatty foods, which provide hedonic pleasure through their taste.

To address this, Khan's team has focused on the study of fat taste receptors, particularly the CD36 and GPR120 receptors located in the taste buds. They have developed several fatty acid analogues known as "lipid decoys."[17] [18] [19] [20] These compounds mimic the taste of fats more intensely than natural dietary fatty acids, thereby binding to the tongue's fat taste receptors and inducing early satiety. This reaction leads to a reduction in the consumption of fat-rich foods and, consequently, body weight in obese models.[21]

In another study, they demonstrated that a GPR120 agonist, TUG-891, can activate the tongue-brain-intestine axis, responsible for the secretion of anorexigenic peptides, which suppress appetite.[22] Furthermore, some of their lipid decoys have shown strong anti-inflammatory activity in various in vitro and in vivo models, adding another layer of therapeutic potential to their research.[23]

Awards and recognition

Mandates

Notes and References

  1. Web site: Naim Akhtar Khan . 2024-06-23 . International Science Council .
  2. Web site: 2023-08-31 . #07-Menu - CTM . 2024-06-23 . fr-FR.
  3. Web site: Pierre . Jeanne . 2021-02-24 . Naim Akhtar Khan : la lutte contre l'obésité . 2024-06-23 . Dijon l'Hebdo . fr-FR.
  4. Web site: STEP : Science and Technology Exchange Program . 2024-06-24 . step.mstfdn.org.
  5. Étude des mécanismes de transport transmembranaire des polyamines : leur importance au cours de la prolifération cellulaire cancéreuse . Rennes 1 . 1990-01-01 . These de doctorat . Naim Akhtar . Khan.
  6. Sayed . Amira . Khan . Naim Akhtar . 2015-12-01 . Le polymorphisme génétique du CD36, un lipido-récepteur, est-il un facteur prédictif de l'obésité à l'âge adulte ? . Médecine/Sciences . fr . 31 . 12 . 1072–1074 . 10.1051/medsci/20153112008 . 26672657 . 0767-0974.
  7. Web site: 2023-01-27 . Le plaisir du gras sans les calories ? . 2024-06-23 . Les Echos . fr.
  8. Web site: EP 3 575 283 A1: LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES . Naim Khan, Sylvain Juge, Aziz Hichami, Jérôme Bayardon, Marie-Laure Louillat-Habermeyer, Baptiste Rugeri . 4 December 2019 . European Patent Office . June 26, 2024 .
  9. Web site: WIPO - Search International and National Patent Collections . 2024-06-23 . patentscope.wipo.int.
  10. Web site: 2022-04-04 . La Start-up dijonnaise Ektah et ses recherches prometteuses contre l'obésité et la prise de poids - Université de Bourgogne . 2024-06-23 . www.u-bourgogne.fr . fr-FR.
  11. Web site: 2023-02-17 . Xavier Boidevezi et Naim Khan veulent lutter contre l'obésité . 2024-06-23 . Le Journal du Palais . fr.
  12. Web site: 2024-04-08 . La start-up dijonnaise EktaH rêve de vaincre l'obésité dans le monde - France Bleu . 2024-06-23 . ici par France Bleu et France 3 . fr.
  13. Web site: 2022-02-04 . EktaH veut créer un spray de leurres lipidiques pour lutter contre l'obésité . 2024-06-23 . Les Echos . fr.
  14. Web site: Committee for Outreach and Engagement . 2024-06-23 . International Science Council .
  15. Web site: Naim Khan nommé "Fellow" de l'Académie des Sciences Physiologiques - L'Institut Agro Dijon . 2024-06-23 . institut-agro-dijon.fr.
  16. Web site: 2023-06-15 . Naim Khan, nommé comme Fellow de l'Académie des Sciences Physiologiques - Université de Bourgogne . 2024-06-23 . www.u-bourgogne.fr . fr-FR.
  17. Besnard . Philippe . Passilly-Degrace . Patricia . Khan . Naim A. . January 2016 . Taste of Fat: A Sixth Taste Modality? . Physiological Reviews . 96 . 1 . 151–176 . 10.1152/physrev.00002.2015 . 1522-1210 . 26631596.
  18. Dramane . Gado . Abdoul-Azize . Souleymane . Hichami . Aziz . Vögtle . Timo . Akpona . Simon . Chouabe . Christophe . Sadou . Hassimi . Nieswandt . Bernhard . Besnard . Philippe . Khan . Naim Akhtar . June 2012 . STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice . The Journal of Clinical Investigation . 122 . 6 . 2267–2282 . 10.1172/JCI59953 . 1558-8238 . 3533500 . 22546859.
  19. Plesník . Jiří . Šerý . Omar . Khan . Amira S. . Bielik . Peter . Khan . Naim A. . February 2018 . The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults . The British Journal of Nutrition . 119 . 4 . 472–478 . 10.1017/S0007114517003981 . 1475-2662 . 29446339.
  20. Daoudi . Hadjer . Plesník . Jiří . Sayed . Amira . Šerý . Omar . Rouabah . Abdelkader . Rouabah . Leila . Khan . Naim Akhtar . 2015-11-04 . Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers . Nutrients . 7 . 11 . 9096–9104 . 10.3390/nu7115455 . free . 2072-6643 . 4663583 . 26556365.
  21. Boutanquoi . Pierre-Marie . Khan . Amira Sayed . Cabeza . Lidia . Jantzen . Lucas . Gautier . Thomas . Yesylevskyy . Semen . Ramseyer . Christophe . Masson . David . Van Waes . Vincent . Hichami . Aziz . Khan . Naim Akhtar . 2024-04-10 . A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia . Cellular and Molecular Life Sciences . 81 . 1 . 176 . 10.1007/s00018-024-05207-1 . 1420-682X . 38598021. 11006773 .
  22. Murtaza . Babar . Hichami . Aziz . Khan . Amira S. . Shimpukade . Bharat . Ulven . Trond . Ozdener . Mehmet Hakan . Khan . Naim A. . February 2020 . Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice . Journal of Lipid Research . 61 . 2 . 133–142 . 10.1194/jlr.RA119000142 . free . 1539-7262 . 6997603 . 31806728.
  23. Boutanquoi . Pierre-Marie . Khan . Amira Sayed . Cabeza . Lidia . Jantzen . Lucas . Gautier . Thomas . Yesylevskyy . Semen . Ramseyer . Christophe . Masson . David . Van Waes . Vincent . Hichami . Aziz . Khan . Naim Akhtar . 2024-04-10 . A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia . Cellular and Molecular Life Sciences . 81 . 1 . 176 . 10.1007/s00018-024-05207-1 . 1420-9071 . 38598021. 11006773 .
  24. Web site: Santé. Le prix Robert Naquet remis au professeur Khan . 2024-06-23 . www.bienpublic.com . FR-fr.
  25. Web site: 2020-11-18 . L'académie de Médecine récompense un professeur de l'Université de Bourgogne pour ses travaux sur l'obésité - France Bleu . 2024-06-23 . ici par France Bleu et France 3 . fr.
  26. Web site: 2020-12-15 . L'Académie de médecine prime Naim Khan, inventeur d'un spray anti-obésité . 2024-06-23 . Le Point . fr.
  27. Web site: L'Académie de Médecine décerne le prix " Alimentation Nutrition " au professeur Naim Khan. - L'Institut Agro Dijon . 2024-06-23 . institut-agro-dijon.fr.
  28. Web site: admin . 2021-02-10 . Les Membres de la SA2P . 2024-06-23 . Société Africaine de Physiologie et Physiopathologie . fr-FR.
  29. Web site: Bodkine . Alexandre . 2024-03-04 . Vers une révolution française dans la lutte contre l'obésité ? . 2024-06-23 . Entreprendre . fr-FR.
  30. Web site: Tabard . Antonin . 2024-02-22 . La start-up EktaH a créé un médicament pour lutter contre l'obésité . 2024-06-23 . ON HEALTH . fr-FR.

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