Nader Rahimi Explained

Nader Rahimi
Image Upright:0.8
Birth Date:22 December 1963
Field:Molecular Biology, Receptor tyrosine kinases, posttranslational modification, Signal transduction
Work Institutions:Boston University
Education:University of Toronto (BS)
Queen's University (PhD)

Nader Rahimi (born December 22, 1963) is a Molecular Biologist and is currently an Associate Professor at the Department of Pathology and Laboratory Medicine at Boston University.[1]

Education

Nader Rahimi received his Bachelor of Science degree in Biochemistry from the University of Toronto in 1991 and received his Ph.D. from Queen's University, Kingston, Canada in 1996.[2] He completed his postdoctoral fellowship at Harvard Medical School in the fields of signal transduction and angiogenesis. [3]

Career

Nader Rahimi has extensively published in the field of signal transduction by receptor tyrosine kinases in particular VEGF receptor tyrosine kinases. His notable works include demonstration of differential function of VEGFR-1 and VEGFR-2 in angiogenesis,[4] identification of lysine methylation as a novel mechanism of activation of VEGFR-2,[5] establishing protein ubiquitination as a major pathway modulating the angiogenic signaling of VEGFR-2.[6] [7] [8] [9] He is also responsible for the discovery of multiple cell surface receptors including, IGPR-1 (TMIGD2),[10] [11] [12] [13] TMIGD1,[14] [15] MINAR1,[16] and MINAR2.[17] His work on COVID-19 resulted in the discovery of CD209L and CD209 as novel receptors [18] [19] and vimentin as an attachment factor for SARS-CoV-2.[20]

Notes and References

  1. Web site: Nader Rahimi, Ph.D. » Pathology & Laboratory Medicine | Boston University.
  2. Web site: Nader Rahimi | School of Medicine.
  3. Web site: Nader Rahimi, PhD | Ophthalmology.
  4. 10747927. 2000. Rahimi. N.. Dayanir. V.. Lashkari. K.. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. The Journal of Biological Chemistry. 275. 22. 16986–92. 10.1074/jbc.M000528200. 22631434. free.
  5. 24300896. 2013. Hartsough. E. J.. Meyer. R. D.. Chitalia. V.. Jiang. Y.. Marquez. V. E.. Zhdanova. I. V.. Weinberg. J.. Costello. C. E.. Rahimi. N.. Lysine methylation promotes VEGFR-2 activation and angiogenesis. Science Signaling. 6. 304. ra104. 10.1126/scisignal.2004289. 4108444.
  6. Web site: A role for protein ubiquitination in BEGFR-2 signaling and angiogenesis. ResearchGate.
  7. 3133358. 2011. Meyer. R. D.. Srinivasan. S.. Singh. A. J.. Mahoney. J. E.. Gharahassanlou. K. R.. Rahimi. N.. PEST Motif Serine and Tyrosine Phosphorylation Controls Vascular Endothelial Growth Factor Receptor 2 Stability and Downregulation. Molecular and Cellular Biology. 31. 10. 2010–2025. 10.1128/MCB.01006-10. 21402774.
  8. A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCγ1 activation and angiogenesis. Amrik J.. Singh. Rosana D.. Meyer. Gyulmagomed. Navruzbekov. Rajani. Shelke. Lei. Duan. Hamid. Band. Susan E.. Leeman. Nader. Rahimi. March 27, 2007. Proceedings of the National Academy of Sciences. 104. 13. 5413–5418. 10.1073/pnas.0700809104. 17372230. 1828708. 2007PNAS..104.5413S. free.
  9. 3969724. 2011. Meyer. R. D.. Husain. D.. Rahimi. N.. C-CBL inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1. Oncogene. 30. 19. 2198–2206. 10.1038/onc.2010.597. 21242968.
  10. https://www.jbc.org/content/early/2019/07/24/jbc.RA119.008548.full.pdf
  11. 5623903. 2017. Woolf. N.. Pearson. B. E.. Bondzie. P. A.. Meyer. R. D.. Lavaei. M.. Belkina. A. C.. Chitalia. V.. Rahimi. N.. Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy. Oncogenesis. 6. 9. e378–. 10.1038/oncsis.2017.77. 28920928.
  12. 5138093. 2016. Wang. Y. H.. Meyer. R. D.. Bondzie. P. A.. Jiang. Y.. Rahimi. I.. Rezazadeh. K.. Mehta. M.. Laver. N. M.. Costello. C. E.. Rahimi. N.. IGPR-1 is Required for Endothelial Cell-Cell Adhesion and Barrier Function. Journal of Molecular Biology. 428. 24 Pt B. 5019–5033. 10.1016/j.jmb.2016.11.003. 27838321.
  13. 3338432. 2012. Rahimi. N.. Rezazadeh. K.. Mahoney. J. E.. Hartsough. E.. Meyer. R. D.. Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis. Molecular Biology of the Cell. 23. 9. 1646–1656. 10.1091/mbc.E11-11-0934. 22419821.
  14. 5839393. 2017. Meyer. R. D.. Zou. X.. Ali. M.. Ersoy. E.. Bondzie. P. A.. Lavaei. M.. Alexandrov. I.. Henderson. J.. Rahimi. N.. TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/P27Kip1 in renal cancer. Oncotarget. 9. 11. 9672–9684. 10.18632/oncotarget.23822. 29515762.
  15. 26342724. 2015. Arafa. E.. Bondzie. P. A.. Rezazadeh. K.. Meyer. R. D.. Hartsough. E.. Henderson. J. M.. Schwartz. J. H.. Chitalia. V.. Rahimi. N.. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. The American Journal of Pathology. 185. 10. 2757–67. 10.1016/j.ajpath.2015.06.006. 4607757.
  16. 6025234. 2018. Ho. R. X.. Meyer. R. D.. Chandler. K. B.. Ersoy. E.. Park. M.. Bondzie. P. A.. Rahimi. N.. Xu. H.. Costello. C. E.. Rahimi. N.. MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth. Journal of Molecular Cell Biology. 10. 3. 195–204. 10.1093/jmcb/mjy002. 29329397.
  17. Web site: Loss of MINAR2 impairs motor function and causes Parkinson's disease-like symptoms in mice | Brain Communications | Oxford Academic . Academic.oup.com . 2021-03-15.
  18. 10.1101/2020.06.22.165803. CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2 and are differentially expressed in lung and kidney epithelial and endothelial cells. 2020. Amraie. Razie. Napoleon. Marc A.. Yin. Wenqing. Berrigan. Jacob. Suder. Ellen. Zhao. Grace. Olejnik. Judith. Gummuluru. Suryaram. Muhlberger. Elke. Chitalia. Vipul. Rahimi. Nader.
  19. COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. Razie. Amraei. Nader. Rahimi. July 15, 2020. Cells. 9. 7. 1652. 10.3390/cells9071652. 32660065. 7407648. free.
  20. Amraei, R., Xia, C., Olejnik, J., White, M.R., Napoleon, M.A., Lotfollahzadeh, S., Hauser, B.M., Schmidt, A.G., Chitalia, V., Muhlberger, E., et al. (2022). Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells. Proc Natl Acad Sci U S A 119.

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