Nadav Ahituv Explained

Nadav Ahituv is the Director for the Institute for Human Genetics at the University of California, San Francisco (USCF).[1] [2] [3] He is also a Professor in the Department of Bioengineering and Therapeutic Sciences and leads the Ahituv Lab at University of California, San Francisco (USCF).[4]

Early life and education

Ahituv received his PhD with distinction in human genetics from Tel-Aviv University, where he worked on hereditary hearing loss.

Research

Ahituv developed cis-regulation therapy (CRT) for genetic diseases that are caused due to changes in gene dosage [5] [6] and adipose manipulation transplantation (AMT) that engineers fat cells and implants them for therapeutic benefits.[7]

The Ahituv Lab investigates gene regulatory elements and their relationship to human diversity and disease. His lab also focuses on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes, including morphological differences between species, drug response, and human disease.[8] The lab is one of the developers of massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements.[9]

Awards and honors

In 2014, Ahituv received the ASCPT Leon I. Goldberg young investigator award from The American Society for Clinical Pharmacology and Therapeutics.[10] In 2024, Ahituv received the Scientific Achievement Award from The American Society of Human Genetics (ASHG).[11]

Notes and References

  1. Web site: Nadav Ahituv UCSF Profiles . 2024-03-05 . profiles.ucsf.edu.
  2. Web site: Nadav Ahituv . 2024-03-05 . Simons Institute for the Theory of Computing . en.
  3. Web site: Speaker Template . 2024-03-05 . PMWC Precision Medicine World Conference . en-US.
  4. Web site: About · Ahituv Lab . 2024-03-05 . Ahituv Lab . en.
  5. Matharu . Navneet . 2018-12-13 . CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency . Science . 363 . 6424 . eaau0629 . 10.1126/science.aau0629 . 1095-9203 . 30545847 . 256746336. 6570489 .
  6. Matharu . Navneet . Ahituv . Nadav . 2020-11-01 . Modulating gene regulation to treat genetic disorders . Nature Reviews Drug Discovery . en . 19 . 11 . 757–775 . 10.1038/s41573-020-0083-7 . 1474-1784 . 33020616 . 256746336.
  7. Nguyen . Hai . 2023-03-29 . Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression . bioRxiv . 10.1101/2023.03.28.534564 . 37034710. 10081280 .
  8. Web site: Nadav Ahituv, PhD . 2024-03-05 . UCSF Institute for Human Genetics . en.
  9. Inoue . Fumitaka . Ahituv . Nadav . 2015-09-01 . Decoding enhancers using massively parallel reporter assays . Genomics . en . 106 . 3 . 159 - 164 . 10.1016/j.ygeno.2015.06.005 . 26072433 . 4540663.
  10. Web site: Nadav Ahituv, PhD Department of Medicine . 2024-03-05 . medicine.ucsf.edu.
  11. Web site: 2024 ASHG Awards . American Society of Human Genetics . 7 October 2024.

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