Sodium sulfate symporter explained
| Symbol: | Na_sulph_symp |
| Na_sulph_symp |
| Pfam: | PF00939 |
| Pfam Clan: | CL0182 |
| Interpro: | IPR001898 |
| Prosite: | PDOC00978 |
| Tcdb: | 2.A.47 |
| Opm Family: | 272 |
| Opm Protein: | 4f35 |
Sodium sulfate symporters are integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions. These sodium symporters can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families, also known as SLC13 transporters, consists of the following proteins:
- Mammalian sodium/sulphate cotransporter.[1]
- Mammalian renal sodium/dicarboxylate cotransporter,[2] which transports succinate and citrate.
- Mammalian intestinal sodium/dicarboxylate cotransporter.
- Chlamydomonas reinhardtii putative sulphur deprivation response regulator SAC1.[3]
This family also includes a number of bacterial symporters.
Notes and References
- Markovich D, Forgo J, Stange G, Biber J, Murer H . Expression cloning of rat renal Na+/SO4(2-) cotransport . Proc. Natl. Acad. Sci. U.S.A. . 90 . 17 . 8073–7 . September 1993 . 7690140 . 47290 . 10.1073/pnas.90.17.8073. free .
- Pajor AM . Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney . Am. J. Physiol. . 270 . 4 Pt 2 . F642-8 . April 1996 . 8967342 . 10.1152/ajprenal.1996.270.4.F642.
- Davies JP, Yildiz FH, Grossman A . Sac1, a putative regulator that is critical for survival of Chlamydomonas reinhardtii during sulfur deprivation . EMBO J. . 15 . 9 . 2150–9 . May 1996 . 8641280 . 450137 . 10.1002/j.1460-2075.1996.tb00568.x.
