The twelfth and final season of NYPD Blue premiered on ABC on September 21, 2004, and concluded on March 1, 2005.
| Bgcolour: |
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| Num Episodes: | 20 |
| Network: | ABC |
| Prev Season: | Season 11 |
| Episode List: | List of NYPD Blue episodes |
| Actor | Character | Main cast | |
|---|---|---|---|
| entire season | |||
| entire season | |||
| entire season | |||
| Baldwin Jones | entire season | ||
| Rita Ortiz | entire season | ||
| John Irvin | entire season | ||
| Thomas Bale | entire season | ||
| Laura Murphy | entire season |
Note: Garcelle Beauvais-Nilon, Jessalyn Gilsig, and John F. O'Donohue did not return for the twelfth season. With the exception of Eddie Gibson being replaced as squad commander, their absences are not explained to the audience.
See also: List of NYPD Blue episodes.