NXT1 explained

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.^{[1] [2] [3]}

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

Further reading

• Katahira J . The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human . EMBO J. . 18 . 9 . 2593–609 . 1999 . 10228171 . 10.1093/emboj/18.9.2593 . 1171339 . Strässer K . Podtelejnikov A . Mann . Matthias . Jung . Jae U. . Hurt . Ed .
• Ossareh-Nazari B . RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro . Mol. Cell. Biol. . 20 . 13 . 4562–71 . 2000 . 10848583 . 10.1128/MCB.20.13.4562-4571.2000 . 85847 . Maison C . Black BE . Levesque . L. . Paschal . B. M. . Dargemont . C. .
• Herold A . TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture . Mol. Cell. Biol. . 20 . 23 . 8996–9008 . 2000 . 11073998 . 10.1128/MCB.20.23.8996-9008.2000 . 86553 . Suyama M . Rodrigues JP . Braun . I. C. . Kutay . U. . Carmo-Fonseca . M. . Bork . P. . Izaurralde . E. .
• Black BE . NXT1 is necessary for the terminal step of Crm1-mediated nuclear export . J. Cell Biol. . 152 . 1 . 141–55 . 2001 . 11149927 . 10.1083/jcb.152.1.141 . 2193657 . Holaska JM . Lévesque L . Ossareh-Nazari . B. . Gwizdek . C. . Dargemont . C. . Paschal . B. M. .
• Jun L . NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation . Curr. Biol. . 11 . 18 . 1381–91 . 2002 . 11566096 . 10.1016/S0960-9822(01)00419-5 . Frints S . Duhamel H . Herold . Andrea . Abad-Rodrigues . Jose . Dotti . Carlos . Izaurralde . Elisa . Marynen . Peter . Froyen . Guy . 18567485 . free . 2001CBio...11.1381J .
• Fribourg S, Braun IC, Izaurralde E, Conti E . Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor . Mol. Cell . 8 . 3 . 645–56 . 2001 . 11583626 . 10.1016/S1097-2765(01)00348-3 . free .
• Wiegand HL . Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes . Mol. Cell. Biol. . 22 . 1 . 245–56 . 2002 . 11739738 . 10.1128/MCB.22.1.245-256.2002 . 134221 . Coburn GA . Zeng Y . Kang . Y. . Bogerd . H. P. . Cullen . B. R. .
• Katahira J . Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling . J. Biol. Chem. . 277 . 11 . 9242–6 . 2002 . 11756420 . 10.1074/jbc.M110007200 . Straesser K . Saiwaki T . Yoneda . Y . Hurt . E . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM . Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export . Mol Cell Biol . 19 . 12 . 8616–24 . Jan 2000 . 10567585 . 84993 . 10.1128/MCB.19.12.8616.
2. Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML . NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells . Mol Cell Biol . 21 . 7 . 2545–54 . Mar 2001 . 11259602 . 86886 . 10.1128/MCB.21.7.2545-2554.2001 .
3. Web site: Entrez Gene: NXT1 NTF2-like export factor 1.