NXPH1 explained

Neurexophilin-1 is a protein that in humans is encoded by the NXPH1 gene.^{[1] [2]}

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons.

Further reading

• Ohira M . Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma . Cancer Lett. . 197 . 1–2 . 63–68 . 2003 . 12880961 . 10.1016/S0304-3835(03)00085-5 . vanc. Morohashi A . Nakamura Y . 3 . Isogai . E . Furuya . K . Hamano . S . Machida . T . Aoyama . M . Fukumura . M .
• Petrenko AG . Structure and evolution of neurexophilin . J. Neurosci. . 16 . 14 . 4360–9 . 1996 . 8699246 . 10.1523/JNEUROSCI.16-14-04360.1996. vanc. Ullrich B . Missler M . 3 . Krasnoperov . V . Rosahl . TW . Südhof . TC . 6578849 . free.
• Missler M, Hammer RE, Südhof TC . Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit . J. Biol. Chem. . 273 . 52 . 34716–34723 . 1999 . 9856994 . 10.1074/jbc.273.52.34716 . free .
• Clarris HJ, McKeown S, Key B . Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb . Int. J. Dev. Biol. . 46 . 4 . 649–52 . 2003 . 12141453 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Scherer SW . Human chromosome 7: DNA sequence and biology . Science . 300 . 5620 . 767–772 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–164 . 2003 . 12853948 . 10.1038/nature01782 . vanc. Fulton RS . Fulton LA . 3 . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Missler M, Sudhof TC . Neurexophilins form a conserved family of neuropeptide-like glycoproteins . J Neurosci . 18 . 10 . 3630–8 . Jun 1998 . 9570794 . 6793134. 10.1523/JNEUROSCI.18-10-03630.1998. free .
2. Web site: Entrez Gene: NXPH1 neurexophilin 1.