NWD1 explained

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species.^[1] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.^[2]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Correa RG, Ware CF, Reed JC . NLRs: Sentinels of innate immunity or cancer culprits? . Oncoscience . 1 . 5 . 308–9 . 2014 . 25594025 . 10.18632/oncoscience.44 . 4278305.

Notes and References

1. Stein C, Caccamo M, Laird G, Leptin M . Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish . Genome Biol. . 8 . 11 . R251 . 2007 . 18039395 . 2258186 . 10.1186/gb-2007-8-11-r251 . free .
2. Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC . 2014 . The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling . Oncotarget . 5 . 6. 1657–1665 . 4039239 . 10.18632/oncotarget.1850 . 24681825.