Nucleoporin 54 Explained

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.^{[1] [2]}

Function

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.

Further reading

• Stoffler D, Fahrenkrog B, Aebi U . The nuclear pore complex: from molecular architecture to functional dynamics . Curr. Opin. Cell Biol. . 11 . 3 . 391–401 . 1999 . 10395558 . 10.1016/S0955-0674(99)80055-6 .
• Bodoor K, Shaikh S, Enarson P, Chowdhury S, Salina D, Raharjo WH, Burke B . Function and assembly of nuclear pore complex proteins . Biochem. Cell Biol. . 77 . 4 . 321–329 . 1999 . 10546895 . 10.1139/bcb-77-4-321 .
• Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ . A complex of nuclear pore proteins required for pore function . J. Cell Biol. . 114 . 1 . 169–183 . 1991 . 2050741 . 2289063 . 10.1083/jcb.114.1.169 .
• Buss F, Stewart M . Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62 . J. Cell Biol. . 128 . 3 . 251–261 . 1995 . 7531196 . 2120351 . 10.1083/jcb.128.3.251 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Guan T, Müller S, Klier G, Panté N, Blevitt JM, Haner M, Paschal B, Aebi U, Gerace L . Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex . Mol. Biol. Cell . 6 . 11 . 1591–1603 . 1996 . 8589458 . 301313 . 10.1091/mbc.6.11.1591 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Popov S, Rexach M, Ratner L, Blobel G, Bukrinsky M . Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex . J. Biol. Chem. . 273 . 21 . 13347–13352 . 1998 . 9582382 . 10.1074/jbc.273.21.13347 . free .
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–9548 . 2000 . 10931946 . 16901 . 10.1073/pnas.160270997 . 2000PNAS...97.9543H . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleoporin p54

Notes and References

1. Hu T, Guan T, Gerace L . Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins . J Cell Biol . 134 . 3 . 589–601 . Sep 1996 . 8707840 . 2120945 . 10.1083/jcb.134.3.589 .
2. Web site: Entrez Gene: NUP54 nucleoporin 54kDa.