Nucleoporin 155 Explained

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.^{[1] [2]}

Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene.

Interactions

NUP155 has been shown to interact with GLE1L.^[3]

Further reading

• Görlich D, Mattaj IW . Nucleocytoplasmic transport . Science . 271 . 5255 . 1513–8 . 1996 . 8599106 . 10.1126/science.271.5255.1513 . 1996Sci...271.1513G . free . 11858/00-001M-0000-002D-1CAE-4 . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . vanc. Ishikawa K . Suyama M . 3 . Kikuno . R . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . Ohara . O . free .
• Zhang X . Genomic organization, transcript variants and comparative analysis of the human nucleoporin 155 (NUP155) gene . Gene . 288 . 1–2 . 9–18 . 2002 . 12034489 . 10.1016/S0378-1119(02)00470-5 . vanc. Yang H . Yu J . 3 . Chen . Cong . Zhang . Guangyu . Bao . Jingyue . Du . Yutao . Kibukawa . Miho . Li . Zhijie .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Rayala HJ . The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155 . Mol. Cell. Proteomics . 3 . 2 . 145–55 . 2004 . 14645504 . 10.1074/mcp.M300106-MCP200 . vanc. Kendirgi F . Barry DM . 3 . Majerus . PW . Wente . SR . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Colland F . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 . vanc. Jacq X . Trouplin V . 3 . Mougin . C . Groizeleau . C . Hamburger . A . Meil . A . Wojcik . J . Legrain . P .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW . Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex . Mol. Biol. Cell . 16 . 5 . 2382–94 . 2005 . 15703211 . 10.1091/mbc.E04-10-0857 . 1087243 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R. 4427026 .

Notes and References

1. Zhang X, Yang H, Corydon MJ, Zhang X, Pedersen S, Korenberg JR, Chen XN, Laporte J, Gregersen N, Niebuhr E, Liu G, Bolund L . Localization of a human nucleoporin 155 gene (NUP155) to the 5p13 region and cloning of its cDNA . Genomics . 57 . 1 . 144–51 . Jun 1999 . 10191094 . 10.1006/geno.1999.5741 .
2. Web site: Entrez Gene: NUP155 nucleoporin 155kDa.
3. Rayala . Heidi J . Kendirgi Frederic . Barry Dianne M . Majerus Philip W . Wente Susan R . Feb 2004 . The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155 . Mol. Cell. Proteomics . 3 . 2 . 145–55 . United States. 1535-9476. 14645504 . 10.1074/mcp.M300106-MCP200 . free .