NUMBL explained

Numb-like protein is a protein that in humans is encoded by the NUMBL gene.^{[1] [2] [3]}

Interactions

NUMBL has been shown to interact with MAP3K7IP2.^[4]

Further reading

• Wong WT, Schumacher C, Salcini AE, etal . A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. . Proc. Natl. Acad. Sci. U.S.A. . 92 . 21 . 9530–4 . 1995 . 7568168 . 10.1073/pnas.92.21.9530 . 40835 . 1995PNAS...92.9530W . free .
• Zhong W, Feder JN, Jiang MM, etal . Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. . Neuron . 17 . 1 . 43–53 . 1996 . 8755477 . 10.1016/S0896-6273(00)80279-2 . free .
• Zhong W, Jiang MM, Weinmaster G, etal . Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. . Development . 124 . 10 . 1887–97 . 1997 . 10.1242/dev.124.10.1887 . 9169836 .
• Roncarati R, Sestan N, Scheinfeld MH, etal . The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 10 . 7102–7 . 2002 . 12011466 . 10.1073/pnas.102192599 . 124535 . 2002PNAS...99.7102R . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . free . 2004CBio...14.1436J .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .

Notes and References

1. Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA . cDNAs with long CAG trinucleotide repeats from human brain . Hum Genet . 100 . 1 . 114–22 . Jul 1997 . 9225980 . 10.1007/s004390050476 . 25999127 .
2. Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP . Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module . Genes Dev . 11 . 17 . 2239–49 . Oct 1997 . 9303539 . 275390 . 10.1101/gad.11.17.2239 .
3. Web site: Entrez Gene: NUMBL numb homolog (Drosophila)-like.
4. Ma . Qi . Zhou Li . Shi Huili . Huo Keke . Jun 2008 . NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation . Cell. Signal. . 20 . 6 . 1044–51 . England. 0898-6568. 18299187 . 10.1016/j.cellsig.2008.01.015 .