Neurotensin receptor 2 explained

Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene belongs to the G protein-coupled receptor family that activates a phosphatidylinositol-calcium second messenger system.^[4] Binding and pharmacological studies demonstrate that this receptor binds Neurotensin (NT) as well as several other ligands already described for Neurotensin receptor 1. NT function is known to be a neuromodulator of dopamine and has hypothermic and analgesic properties in the brain and some peripheral organ function as well.^[5] NTS2 is found mostly in the brain through Northern-blot analysis.Unlike NTS1, NTS2 has a low affinity with NT and a high sensitivity to levocabastine, an antihistamine, which competes with NT for binding.

See also

• Neurotensin receptor

Further reading

• Vincent JP, Mazella J, Kitabgi P . Neurotensin and neurotensin receptors . Trends in Pharmacological Sciences . 20 . 7 . 302–9 . Jul 1999 . 10390649 . 10.1016/S0165-6147(99)01357-7 .
• Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP . Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain . The Journal of Neuroscience . 16 . 18 . 5613–20 . Sep 1996 . 8795617 . 10.1523/jneurosci.16-18-05613.1996. 6578974 . free .
• Ramez M, Bagot M, Nikolova M, Boumsell L, Vita N, Chalon P, Caput D, Ferrara P, Bensussan A . Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes . The Journal of Investigative Dermatology . 117 . 3 . 687–93 . Sep 2001 . 11564178 . 10.1046/j.0022-202x.2001.01439.x . free .
• Martin S, Vincent JP, Mazella J . Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue . Journal of Cell Science . 115 . Pt 1 . 165–73 . Jan 2002 . 10.1242/jcs.115.1.165 . 11801734 . free .
• Bourcier T, Rondeau N, Paquet S, Forgez P, Lombet A, Pouzaud F, Rostène W, Borderie V, Laroche L . Expression of neurotensin receptors in human corneal keratocytes . Investigative Ophthalmology & Visual Science . 43 . 6 . 1765–71 . Jun 2002 . 12036977 .
• Leyton J, Garcia-Marin L, Jensen RT, Moody TW . Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells . European Journal of Pharmacology . 442 . 3 . 179–86 . May 2002 . 12065070 . 10.1016/S0014-2999(02)01539-X .
• Somaï S, Gompel A, Rostène W, Forgez P . Neurotensin counteracts apoptosis in breast cancer cells . Biochemical and Biophysical Research Communications . 295 . 2 . 482–8 . Jul 2002 . 12150975 . 10.1016/S0006-291X(02)00703-9 .
• Holst B, Holliday ND, Bach A, Elling CE, Cox HM, Schwartz TW . Common structural basis for constitutive activity of the ghrelin receptor family . The Journal of Biological Chemistry . 279 . 51 . 53806–17 . Dec 2004 . 15383539 . 10.1074/jbc.M407676200 . free .

External links

• Web site: Neurotensin Receptors: NTS₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-05 . 2016-03-03 . https://web.archive.org/web/20160303202002/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3005 . dead .

Notes and References

1. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D . Molecular cloning of a levocabastine-sensitive neurotensin binding site . FEBS Letters . 386 . 2–3 . 91–4 . May 1996 . 8647296 . 10.1016/0014-5793(96)00397-3 . 5802578 . free .
2. Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P . Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells . European Journal of Pharmacology . 360 . 2–3 . 265–72 . Nov 1998 . 9851594 . 10.1016/S0014-2999(98)00678-5 .
3. Web site: Entrez Gene: NTSR2 neurotensin receptor 2.
4. Web site: Entrez Gene: NTSR2 neurotensin receptor 2 .
5. Vincent . Jean-Pierre . Mazella . Jean . Kitabgi . Patrick . July 1999 . Neurotensin and neurotensin receptors . Trends in Pharmacological Sciences . 20 . 7 . 302–309 . 10.1016/s0165-6147(99)01357-7 . 0165-6147.