Neurotrimin Explained

Neurotrimin is a protein that in humans is encoded by the NTM gene.^{[1] [2]}

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML) on chromosome 11. Multiple alternatively spliced variants have been found but only two variants have had their full-length sequences determined.^[3]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Wistow G, Bernstein SL, Wyatt MK, etal . Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. . Mol. Vis. . 8 . 205–20 . 2002 . 12107410 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Sellar GC, Watt KP, Rabiasz GJ, etal . OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. . Nat. Genet. . 34 . 3 . 337–43 . 2003 . 12819783 . 10.1038/ng1183 . 24411276 .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Liu J, Li G, Peng X, etal . The cloning and preliminarily functional analysis of the human neurotrimin gene. . Science in China Series C: Life Sciences . 47 . 2 . 158–64 . 2004 . 15379248 . 10.1360/03yc0072 . 12684887 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .

Notes and References

1. Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D'Eustachio P, Salzer JL . Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules . J Neurosci . 15 . 3 Pt 2 . 2141–56 . Apr 1995 . 7891157 . 6578143. 10.1523/JNEUROSCI.15-03-02141.1995. free .
2. Web site: Entrez Gene: HNT neurotrimin.
3. Web site: Entrez Gene: HNT neurotrimin.