NSL1 explained

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.^[1]

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.

Interactions

NSL1 has been shown to interact with MIS12^[2] and DSN1.^[2]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Obuse C, Iwasaki O, Kiyomitsu T, etal . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. . Nat. Cell Biol. . 6 . 11 . 1135–41 . 2004 . 15502821 . 10.1038/ncb1187 . 39408000 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Nousiainen M, Silljé HH, Sauer G, etal . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . 2006PNAS..103.5391N . free .
• Kline SL, Cheeseman IM, Hori T, etal . The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. . J. Cell Biol. . 173 . 1 . 9–17 . 2006 . 16585270 . 10.1083/jcb.200509158 . 2063780 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Grundt K, Haga IV, Huitfeldt HS, Ostvold AC . Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS. . Biochim. Biophys. Acta . 1773 . 9 . 1398–406 . 2007 . 17604136 . 10.1016/j.bbamcr.2007.05.013 .

Notes and References

1. Web site: Entrez Gene: NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae).
2. Obuse . Chikashi . Iwasaki Osamu . Kiyomitsu Tomomi . Goshima Gohta . Toyoda Yusuke . Yanagida Mitsuhiro . Nov 2004 . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 . Nat. Cell Biol. . 6 . 11 . 1135–41 . England. 1465-7392. 15502821 . 10.1038/ncb1187 . 39408000 .