WHSC1L1 explained

Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene.^{[1] [2]}

This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.^[2]

The WHSC1L1 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.^{[3] [4]}

Further reading

• Angrand PO, Apiou F, Stewart AF, etal . NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. . Genomics . 74 . 1 . 79–88 . 2001 . 11374904 . 10.1006/geno.2001.6524 .
• Stec I, van Ommen GJ, den Dunnen JT . WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. . Genomics . 76 . 1–3 . 5–8 . 2001 . 11549311 . 10.1006/geno.2001.6581 .
• Rosati R, La Starza R, Veronese A, etal . NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15) . Blood . 99 . 10 . 3857–60 . 2002 . 11986249 . 10.1182/blood.V99.10.3857 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Tonon G, Wong KK, Maulik G, etal . High-resolution genomic profiles of human lung cancer . Proc. Natl. Acad. Sci. U.S.A. . 102 . 27 . 9625–30 . 2005 . 15983384 . 10.1073/pnas.0504126102 . 1160520 . 2005PNAS..102.9625T . free .
• Kim SM, Kee HJ, Eom GH, etal . Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity . Biochem. Biophys. Res. Commun. . 345 . 1 . 318–23 . 2006 . 16682010 . 10.1016/j.bbrc.2006.04.095 .

Notes and References

1. Stec I, Nagl SB, van Ommen GJ, den Dunnen JT . The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? . FEBS Lett . 473 . 1 . 1–5 . Jun 2000 . 10802047 . 10.1016/S0014-5793(00)01449-6 . 26290698 .
2. Web site: Entrez Gene: WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1.
3. Kang. D. Cho. HS. Toyokawa. G. Kogure. M. Yamane. Y. Iwai. Y. Hayami. S. Tsunoda. T. Field. HI. Matsuda. K. Neal. DE. Ponder. BA. Maehara. Y. Nakamura. Y. Hamamoto. R. The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.. Genes, Chromosomes & Cancer. Feb 2013. 52. 2. 126–39. 23011637. 10.1002/gcc.22012. 41047322.
4. Chen. Y. McGee. J. Chen. X. Doman. TN. Gong. X. Zhang. Y. Hamm. N. Ma. X. Higgs. RE. Bhagwat. SV. Buchanan. S. Peng. SB. Staschke. KA. Yadav. V. Yue. Y. Kouros-Mehr. Hosein. Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets.. PLOS ONE. 2014. 9. 5. e98293. 24874471. 10.1371/journal.pone.0098293. 4038530. 2014PLoSO...998293C. free.