Hepatitis C virus nonstructural protein 3 explained

Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease.^{[1] [2]} C-terminal two-thirds of the protein also acts as helicase and nucleoside triphosphatase.^[3] First (N-terminal) 180 aminoacids of NS3 has additional role as cofactor domains for NS2 protein.^[4]

See also

• Boceprevir, sovaprevir, paritaprevir and telaprevir - drugs targeting this protein^[5]

External links

• http://www.uniprot.org/uniprot/Q91RS4

Notes and References

1. Hijikata . M. . etal . 1993 . Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus . Proc. Natl. Acad. Sci. USA . 90 . 22 . 10773–10777 . 10.1073/pnas.90.22.10773 . 7504283 . 47860 . 1993PNAS...9010773H . free .
2. 10.1074/jbc.R110.125294 . 285 . Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target . 2010 . Journal of Biological Chemistry . 22725–22731 . Raney . Kevin D. . Sharma . Suresh D. . Moustafa . Ibrahim M. . Cameron . Craig E.. 30 . 20457607 . 2906261 . free .
3. http://jvi.asm.org/content/79/14/8687.abstract Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase
4. 19282477 . 10.1073/pnas.0810950106 . 2663979 . 106 . Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3 . 2009 . Proc Natl Acad Sci U S A . 5342–7 . Schregel . V . Jacobi . S . Penin . F . Tautz . N. 13 . 2009PNAS..106.5342S . free .
5. Web site: NS3/4A Protease Inhibitors - DrugBank.