NRN1 explained

Neuritin 1 is a protein that in humans is encoded by the NRN1 gene.^[1]

Function

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Further reading

• Le Jan S, Le Meur N, Cazes A, Philippe J, Le Cunff M, Léger J, Corvol P, Germain S . Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer . FEBS Lett. . 580 . 14 . 3395–400 . 2006 . 16723126 . 10.1016/j.febslet.2006.05.011 . 10052776 . free . 10.1.1.326.1157 .
• Fujino T, Wu Z, Lin WC, Phillips MA, Nedivi E . cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival . J. Comp. Neurol. . 507 . 5 . 1831–45 . 2008 . 18265009 . 2828060 . 10.1002/cne.21649 .
• Chandler D, Dragović M, Cooper M, Badcock JC, Mullin BH, Faulkner D, Wilson SG, Hallmayer J, Howell S, Rock D, Palmer LJ, Kalaydjieva L, Jablensky A . Impact of Neuritin 1 (NRN1) polymorphisms on fluid intelligence in schizophrenia . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 153B . 2 . 428–437 . 2010 . 19569075 . 10.1002/ajmg.b.30996 . 24983584 .
• Zhang L, Zhao Y, Wang CG, Fei Z, Wang Y, Li L, Li L, Zhen HN . Neuritin expression and its relation with proliferation, apoptosis, and angiogenesis in human astrocytoma . Med. Oncol. . 28 . 3 . 907–12 . 2011 . 20405246 . 10.1007/s12032-010-9537-9 . 25680435 .
• Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M . Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits . Proc. Natl. Acad. Sci. U.S.A. . 108 . 25 . 10337–42 . 2011 . 21652774 . 3121858 . 10.1073/pnas.1104928108 . 2011PNAS..10810337A . free .
• Gao R, Wang L, Sun J, Nie K, Jian H, Gao L, Liao X, Zhang H, Huang J, Gan S . MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression . FEBS Lett. . 588 . 17 . 3225–32 . 2014 . 25036738 . 10.1016/j.febslet.2014.07.004 . 24215014 . free .
• Choi Y, Lee K, Ryu J, Kim HG, Jeong AY, Woo RS, Lee JH, Hyun JW, Hahn S, Kim JH, Kim HS . Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease . PLOS ONE . 9 . 8 . e104121 . 2014 . 25101829 . 4125179 . 10.1371/journal.pone.0104121 . 2014PLoSO...9j4121C . free .
• Wang X, Liu C, Xu F, Cui L, Tan S, Chen R, Yang L, Huang J . Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells . Cell. Mol. Biol. Lett. . 20 . 3 . 466–74 . 2015 . 26208391 . 10.1515/cmble-2015-0026 . free .
• Fatjó-Vilas M, Prats C, Pomarol-Clotet E, Lázaro L, Moreno C, González-Ortega I, Lera-Miguel S, Miret S, Muñoz MJ, Ibáñez I, Campanera S, Giralt-López M, Cuesta MJ, Peralta V, Ortet G, Parellada M, González-Pinto A, McKenna PJ, Fañanás L . Involvement of NRN1 gene in schizophrenia-spectrum and bipolar disorders and its impact on age at onset and cognitive functioning . World J. Biol. Psychiatry . 17 . 2 . 129–39 . 2016 . 26700405 . 10.3109/15622975.2015.1093658 . 2445/69596 . 39722608 . free .

Notes and References

1. Web site: Entrez Gene: Neuritin 1. 2017-12-15.