Neuregulin 2 Explained

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.^[1] ^[2] ^[3]

Function

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.

Further reading

Chang H, Riese DJ, Gilbert W, etal . Ligands for ErbB-family receptors encoded by a neuregulin-like gene . Nature . 387 . 6632 . 509–12 . 1997 . 9168114 . 10.1038/387509a0 . 1997Natur.387R.509C . 4359654 .
Carraway KL, Weber JL, Unger MJ, etal . Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases . Nature . 387 . 6632 . 512–6 . 1997 . 9168115 . 10.1038/387512a0 . 1997Natur.387R.512C . 4310136 .
Busfield SJ, Michnick DA, Chickering TW, etal . Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus . Mol. Cell. Biol. . 17 . 7 . 4007–14 . 1997 . 9199335 . 10.1128/MCB.17.7.4007. 232253 .
Higashiyama S, Horikawa M, Yamada K, etal . A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4 . J. Biochem. . 122 . 3 . 675–80 . 1998 . 9348101 . 10.1093/oxfordjournals.jbchem.a021806.
Reddy PH, Stockburger E, Gillevet P, Tagle DA . Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method . Genomics . 46 . 2 . 174–82 . 1998 . 9417904 . 10.1006/geno.1997.5044 .
Ring HZ, Chang H, Guilbot A, etal . The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q . Hum. Genet. . 104 . 4 . 326–32 . 1999 . 10369162 . 10.1007/s004390050961 . 8684113 .
Yamada K, Ichino N, Nishii K, etal . Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA . Gene . 255 . 1 . 15–24 . 2000 . 10974560 . 10.1016/S0378-1119(00)00309-7 .
Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
Nakano N, Higashiyama S, Ohmoto H, etal . The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis . J. Biol. Chem. . 279 . 12 . 11465–70 . 2004 . 14722120 . 10.1074/jbc.M311045200 . free .
Ponomareva ON, Ma H, Dakour R, etal . Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing . Neuroscience . 134 . 2 . 495–503 . 2005 . 15961242 . 10.1016/j.neuroscience.2005.04.028 . 37483720 .
Fan BJ, Ko WC, Wang DY, etal . Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene . Mol. Vis. . 13 . 779–84 . 2007 . 17563728 . 2768763 .

Notes and References

Web site: Entrez Gene: NRG2 neuregulin 2.
Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ . Ligands for ErbB-family receptors encoded by a neuregulin-like gene . Nature . 387 . 6632 . 509–12 . May 1997 . 9168114 . 10.1038/387509a0 . 1997Natur.387R.509C . 4359654 .
Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C . Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases . Nature . 387 . 6632 . 512–6 . May 1997 . 9168115 . 10.1038/387512a0 . 1997Natur.387R.512C . 4310136 .