NRD1 explained

Nardilysin is a protein that in humans is encoded by the NRD1 gene.^{[1] [2] [3]}

Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.^[4]

Further reading

• Seidah NG, Prat A . Precursor convertases in the secretory pathway, cytosol and extracellular milieu. . Essays Biochem. . 38 . 79–94 . 2003 . 12463163 . 10.1042/bse0380079.
• Hospital V, Prat A . Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. . Protein Pept. Lett. . 11 . 5 . 501–8 . 2005 . 15544571 . 10.2174/0929866043406508 .
• Winter AG, Pierotti AR . Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. . Biochem. J. . 351 . 3. 755–64 . 2001 . 11042131 . 10.1042/0264-6021:3510755. 1221416 .
• Nishi E, Prat A, Hospital V, etal . N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. . EMBO J. . 20 . 13 . 3342–50 . 2001 . 11432822 . 10.1093/emboj/20.13.3342 . 125525 .
• Ma Z, Csuhai E, Chow KM, Hersh LB . Expression of the acidic stretch of nardilysin as a functional binding domain. . Biochemistry . 40 . 31 . 9447–52 . 2001 . 11478915 . 10.1021/bi010538x .
• Hospital V, Nishi E, Klagsbrun M, etal . The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). . Biochem. J. . 367 . Pt 1 . 229–38 . 2003 . 12095415 . 10.1042/BJ20020822 . 1222870 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chow KM, Oakley O, Goodman J, etal . Nardilysin cleaves peptides at monobasic sites. . Biochemistry . 42 . 7 . 2239–44 . 2003 . 12590613 . 10.1021/bi027178d .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Nishi E, Hiraoka Y, Yoshida K, etal . Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. . J. Biol. Chem. . 281 . 41 . 31164–72 . 2006 . 16923819 . 10.1074/jbc.M601316200 . free .
• Bernstein HG, Stricker R, Dobrowolny H, etal . Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. . Neuroscience . 146 . 4 . 1513–23 . 2007 . 17442499 . 10.1016/j.neuroscience.2007.02.057 . 8060302 .

Notes and References

1. Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P . Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family . Biochem J . 327 . 3. 773–9 . May 1998 . 10.1042/bj3270773 . 9581555 . 1218856 .
2. Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R . Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues . Genomics . 47 . 2 . 238–45 . Apr 1998 . 9479496 . 10.1006/geno.1997.5078 .
3. Web site: Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase).
4. Nishi . E . Prat A . Hospital V . Elenius K . Klagsbrun M . Jul 2001 . N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration . EMBO J. . 20 . 13 . 3342–50 . England. 0261-4189. 11432822 . 10.1093/emboj/20.13.3342 . 125525 .