COUP-TFI explained

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.^{[1] [2]} This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.^{[3] [4]} COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.^[5]

Interactions

COUP-TFI has been shown to interact with:

• BCL11A,^[6]
• BCL11B,^[6]
• COPS2,^[7] and
• ESR1.^[8]

Clinical

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.^[9]

References

Further reading

• Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM . Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling . Proceedings of the National Academy of Sciences of the United States of America . 89 . 4 . 1448–52 . Feb 1992 . 1311101 . 48468 . 10.1073/pnas.89.4.1448 . 1992PNAS...89.1448K . free .
• Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA . Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein . Molecular Endocrinology . 6 . 9 . 1468–78 . Sep 1992 . 10.1210/mend.6.9.1331778 . 1331778 . 24291055 . free .
• Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW . Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II) . The Journal of Biological Chemistry . 267 . 25 . 17617–23 . Sep 1992 . 10.1016/S0021-9258(19)37087-5 . 1517211 . free .
• Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW . COUP transcription factor is a member of the steroid receptor superfamily . Nature . 340 . 6229 . 163–6 . Jul 1989 . 2739739 . 10.1038/340163a0 . 1989Natur.340..163W . 4364164 .
• Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T . Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other . Nucleic Acids Research . 16 . 23 . 11057–74 . Dec 1988 . 2905047 . 338996 . 10.1093/nar/16.23.11057 .
• Sawaya BE, Rohr O, Aunis D, Schaeffer E . Chicken ovalbumin upstream promoter transcription factor, a transcriptional activator of HIV-1 gene expression in human brain cells . The Journal of Biological Chemistry . 271 . 38 . 23572–6 . Sep 1996 . 8798567 . 10.1074/jbc.271.38.23572 . free .
• Rohr O, Aunis D, Schaeffer E . COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells . The Journal of Biological Chemistry . 272 . 49 . 31149–55 . Dec 1997 . 9388268 . 10.1074/jbc.272.49.31149 . free .
• Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A . Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily . Molecular and Cellular Biology . 19 . 5 . 3383–94 . May 1999 . 10207062 . 84131 . 10.1128/mcb.19.5.3383.
• Klinge CM, Kaur K, Swanson HI . The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1 . Archives of Biochemistry and Biophysics . 373 . 1 . 163–74 . Jan 2000 . 10620335 . 10.1006/abbi.1999.1552 .
• Rohr O, Schwartz C, Hery C, Aunis D, Tardieu M, Schaeffer E . The nuclear receptor chicken ovalbumin upstream promoter transcription factor interacts with HIV-1 Tat and stimulates viral replication in human microglial cells . The Journal of Biological Chemistry . 275 . 4 . 2654–60 . Jan 2000 . 10644726 . 10.1074/jbc.275.4.2654 . free .
• Sugiyama T, Wang JC, Scott DK, Granner DK . Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene . The Journal of Biological Chemistry . 275 . 5 . 3446–54 . Feb 2000 . 10652338 . 10.1074/jbc.275.5.3446 . free .
• Vlahou A, Flytzanis CN . Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle . Developmental Biology . 218 . 2 . 284–98 . Feb 2000 . 10656770 . 10.1006/dbio.1999.9456 . free .
• Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M . Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors . The Journal of Biological Chemistry . 275 . 14 . 10315–22 . Apr 2000 . 10744719 . 2819356 . 10.1074/jbc.275.14.10315 . free .
• Gay F, Anglade I, Gong Z, Salbert G . The LIM/homeodomain protein islet-1 modulates estrogen receptor functions . Molecular Endocrinology . 14 . 10 . 1627–48 . Oct 2000 . 11043578 . 10.1210/me.14.10.1627 . free .
• You M, Fischer M, Cho WK, Crabb D . Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors . Archives of Biochemistry and Biophysics . 398 . 1 . 79–86 . Feb 2002 . 11811951 . 10.1006/abbi.2001.2713 . free .
• Lin F, Kolluri SK, Chen GQ, Zhang XK . Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor . The Journal of Biological Chemistry . 277 . 24 . 21414–22 . Jun 2002 . 11934895 . 10.1074/jbc.M201885200 . free .
• Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F . Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK . The EMBO Journal . 21 . 13 . 3443–53 . Jul 2002 . 12093745 . 126093 . 10.1093/emboj/cdf344 .
• Yu X, Mertz JE . Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4alpha and COUP-TF1 . Journal of Virology . 77 . 4 . 2489–99 . Feb 2003 . 12551987 . 141100 . 10.1128/JVI.77.4.2489-2499.2003 .

Notes and References

1. Web site: Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1.
2. Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY . Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes . Genomics . 29 . 1 . 240–6 . Sep 1995 . 8530078 . 10.1006/geno.1995.1237 . free .
3. Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW . Identification of two factors required for transcription of the ovalbumin gene . Molecular and Cellular Biology . 6 . 12 . 4259–67 . Dec 1986 . 3796602 . 367207 . 10.1128/MCB.6.12.4259 .
4. Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW . Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) . Cell . 50 . 5 . 701–9 . Aug 1987 . 3040258 . 10.1016/0092-8674(87)90328-X . 25136877 .
5. Ming-Jer Tsai . Tsai SY, Tsai MJ . Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age . Endocrine Reviews . 18 . 2 . 229–40 . Apr 1997 . 10.1210/edrv.18.2.0294 . 9101138 . free .
6. Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M . Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors . The Journal of Biological Chemistry . 275 . 14 . 10315–22 . Apr 2000 . 10744719 . 2819356 . 10.1074/jbc.275.14.10315 . free .
7. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A . Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily . Molecular and Cellular Biology . 19 . 5 . 3383–94 . May 1999 . 10207062 . 84131 . 10.1128/mcb.19.5.3383.
8. Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F . Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK . The EMBO Journal . 21 . 13 . 3443–53 . Jul 2002 . 12093745 . 126093 . 10.1093/emboj/cdf344 .
9. Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62