Testicular receptor 2 explained

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.^{[1] [2]} TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

• Androgen receptor,^[3]
• Estrogen receptor alpha,^[4]
• HDAC3,^{[5] [6] [7]} and
• HDAC4.^{[6] [7]}

See also

• Testicular receptor

Further reading

• Chang C, Kokontis J . Identification of a new member of the steroid receptor super-family by cloning and sequence analysis . Biochemical and Biophysical Research Communications . 155 . 2 . 971–7 . Sep 1988 . 3421977 . 10.1016/S0006-291X(88)80591-6 .
• Lin DL, Wu SQ, Chang C . The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily . Endocrine . 8 . 2 . 123–34 . Apr 1998 . 9704569 . 10.1385/ENDO:8:2:123 . 23712655 .
• Lee CH, Chinpaisal C, Wei LN . A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 . The Journal of Biological Chemistry . 273 . 39 . 25209–15 . Sep 1998 . 9737983 . 10.1074/jbc.273.39.25209 . free .
• Lee CH, Chinpaisal C, Wei LN . Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2 . Molecular and Cellular Biology . 18 . 11 . 6745–55 . Nov 1998 . 9774688 . 109258 . 10.1128/mcb.18.11.6745.
• Yu Z, Lee CH, Chinpaisal C, Wei LN . A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2 . The Journal of Endocrinology . 159 . 1 . 53–60 . Oct 1998 . 9795341 . 10.1677/joe.0.1590053 . free .
• Franco PJ, Farooqui M, Seto E, Wei LN . The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases . Molecular Endocrinology . 15 . 8 . 1318–28 . Aug 2001 . 11463856 . 10.1210/mend.15.8.0682 . free .
• Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD . An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer . The EMBO Journal . 21 . 13 . 3434–42 . Jul 2002 . 12093744 . 126089 . 10.1093/emboj/cdf340 .
• Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C . Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor . The Journal of Biological Chemistry . 277 . 37 . 33571–9 . Sep 2002 . 12093804 . 10.1074/jbc.M203531200 . free .
• Inui S, Lee YF, Chang E, Shyr CR, Chang C . Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes . Journal of Dermatological Science . 31 . 1 . 65–71 . Feb 2003 . 12615366 . 10.1016/S0923-1811(02)00152-4 .
• Franco PJ, Li G, Wei LN . Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase . Molecular and Cellular Endocrinology . 206 . 1–2 . 1–12 . Aug 2003 . 12943985 . 10.1016/S0303-7207(03)00254-5 . 19487189 .
• Mu X, Chang C . TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 . The Prostate . 57 . 2 . 129–33 . Oct 2003 . 12949936 . 10.1002/pros.10282 . 24134119 .
• Li G, Franco PJ, Wei LN . Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 . Biochemical and Biophysical Research Communications . 310 . 2 . 384–90 . Oct 2003 . 14521922 . 10.1016/j.bbrc.2003.08.145 .
• Lin YL, Wang YH, Lee HJ . Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A . Biochemical and Biophysical Research Communications . 350 . 2 . 430–6 . Nov 2006 . 17010934 . 10.1016/j.bbrc.2006.09.061 .

Notes and References

1. Web site: Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1.
2. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y . Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains . Biochemical and Biophysical Research Communications . 165 . 2 . 735–41 . Dec 1989 . 2597158 . 10.1016/S0006-291X(89)80028-2 .
3. Mu X, Chang C . TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 . The Prostate . 57 . 2 . 129–33 . Oct 2003 . 12949936 . 10.1002/pros.10282 . 24134119 .
4. Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C . Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor . The Journal of Biological Chemistry . 277 . 37 . 33571–9 . Sep 2002 . 12093804 . 10.1074/jbc.M203531200 . free .
5. Li G, Franco PJ, Wei LN . Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 . Biochemical and Biophysical Research Communications . 310 . 2 . 384–90 . Oct 2003 . 14521922 . 10.1016/j.bbrc.2003.08.145 .
6. Franco PJ, Li G, Wei LN . Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase . Molecular and Cellular Endocrinology . 206 . 1–2 . 1–12 . Aug 2003 . 12943985 . 10.1016/S0303-7207(03)00254-5 . 19487189 .
7. Franco PJ, Farooqui M, Seto E, Wei LN . The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases . Molecular Endocrinology . 15 . 8 . 1318–28 . Aug 2001 . 11463856 . 10.1210/mend.15.8.0682 . free .