Insulin receptor substrate explained

Insulin receptor substrate (IRS) is an important ligand in the insulin response of human cells.

IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.

Genes

• (see also Insulin receptor substrate 1)
• (see also Insulin receptor substrate 2)
• - a pseudogene

References

• van der Geer P, Wiley S, Pawson T . Re-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site . Oncogene . 18 . 20 . 3071–5 . 1999 . 10340378 . 10.1038/sj.onc.1202879. free .