NPW explained

NPW is a gene that in humans encodes Neuropeptide W protein.^{[1] [2] [3]}

Neuropeptide W (NPW) is an endogenous peptide ligand for GPR8 (MIM 600731), a G protein-coupled receptor.[supplied by OMIM]^[3]

Further reading

• Singh G, Davenport AP . Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. . Br. J. Pharmacol. . 148 . 8 . 1033–41 . 2006 . 16847439 . 10.1038/sj.bjp.0706825 . 1752024 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Shimomura Y, Harada M, Goto M, etal . Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. . J. Biol. Chem. . 277 . 39 . 35826–32 . 2002 . 12130646 . 10.1074/jbc.M205337200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tanaka H, Yoshida T, Miyamoto N, etal . Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. . Proc. Natl. Acad. Sci. U.S.A. . 100 . 10 . 6251–6 . 2003 . 12719537 . 10.1073/pnas.0837789100 . 156358 . 2003PNAS..100.6251T . free .
• Mondal MS, Yamaguchi H, Date Y, etal . A role for neuropeptide W in the regulation of feeding behavior. . Endocrinology . 144 . 11 . 4729–33 . 2003 . 12959997 . 10.1210/en.2003-0536 . free .
• Mazzocchi G, Rebuffat P, Ziolkowska A, etal . G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. . J. Clin. Endocrinol. Metab. . 90 . 6 . 3466–71 . 2005 . 15797961 . 10.1210/jc.2004-2132 . free .
• Andreis PG, Rucinski M, Neri G, etal . Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects. . Int. J. Mol. Med. . 16 . 6 . 1021–8 . 2006 . 16273281 . 10.3892/ijmm.16.6.1021.
• Mondal MS, Yamaguchi H, Date Y, etal . Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. . J. Endocrinol. . 188 . 1 . 49–57 . 2006 . 16394174 . 10.1677/joe.1.06195 . free .

Notes and References

1. Fujii R, Yoshida H, Fukusumi S, Habata Y, Hosoya M, Kawamata Y, Yano T, Hinuma S, Kitada C, Asami T, Mori M, Fujisawa Y, Fujino M . Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7 . J Biol Chem . 277 . 37 . 34010–6 . Sep 2002 . 12118011 . 10.1074/jbc.M205883200 . free .
2. Brezillon S, Lannoy V, Franssen JD, Le Poul E, Dupriez V, Lucchetti J, Detheux M, Parmentier M . Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 . J Biol Chem . 278 . 2 . 776–83 . Jan 2003 . 12401809 . 10.1074/jbc.M206396200 . free .
3. Web site: Entrez Gene: NPW neuropeptide W.