NPTX1 explained
Neuronal pentraxin-1 (NP1) is a protein that in humans is encoded by the NPTX1 gene.[1] [2]
Function
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.[2]
Further reading
- Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS . Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. . J. Biol. Chem. . 275 . 23 . 17786–92 . 2000 . 10748068 . 10.1074/jbc.M002254200 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
- Abad MA, Enguita M, DeGregorio-Rocasolano N, etal . Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain. . J. Neurosci. . 26 . 49 . 12735–47 . 2006 . 17151277 . 6674827 . 10.1523/JNEUROSCI.0575-06.2006 . free .
- Takahashi T, Strittmatter SM . Plexina1 autoinhibition by the plexin sema domain. . Neuron . 29 . 2 . 429–39 . 2001 . 11239433 . 10.1016/S0896-6273(01)00216-1. free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Poulsen TT, Pedersen N, Perin MS, etal . Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. . Lung Cancer . 50 . 3 . 329–37 . 2005 . 16115696 . 10.1016/j.lungcan.2005.06.011 .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129.
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
Notes and References
- Omeis IA, Hsu YC, Perin MS . Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization . Genomics . 36 . 3 . 543–5 . September 1996 . 8884281 . 10.1006/geno.1996.0503 .
- Web site: Entrez Gene: neuronal pentraxin I.
