NPR1 explained

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).^[1]

It is localized in the kidney^[2] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.^[2]

See also

• Atrial natriuretic peptide receptor

Further reading

• Pandey KN . Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments. . Mol. Cell. Biochem. . 230 . 1–2 . 61–72 . 2002 . 11952097 . 10.1023/A:1014240006767 . 10397726 .
• Lucarelli K, Iacoviello M, Dessì-Fulgheri P, etal . [Natriuretic peptides and essential arterial hypertension] . Italian Heart Journal Supplement . 3 . 11 . 1085–91 . 2003 . 12506509 .
• Pandey KN . Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A . Peptides . 26 . 6 . 985–1000 . 2005 . 15911067 . 10.1016/j.peptides.2004.12.020 . 34452043 .
• Garg R, Pandey KN . Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression . Peptides . 26 . 6 . 1009–23 . 2005 . 15911069 . 10.1016/j.peptides.2004.09.022 . 33508201 .

Notes and References

1. Web site: Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A).
2. http://biogps.gnf.org/#goto=genereport&id=4881 BioGPS > NPR1