NPM3 explained

Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene.^{[1] [2]}

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones.^[3]

Further reading

• Philpott A, Krude T, Laskey RA . Nuclear chaperones. . Semin. Cell Dev. Biol. . 11 . 1 . 7–14 . 2000 . 10736259 . 10.1006/scdb.1999.0346 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Andersen JS, Lam YW, Leung AK, etal . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• MacArthur CA, Shackleford GM . Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin. . Genomics . 42 . 1 . 137–40 . 1997 . 9177783 . 10.1006/geno.1997.4353 .

Notes and References

1. Shackleford GM, Ganguly A, MacArthur CA . Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones . BMC Genomics . 2 . 8 . Jul 2003 . 11722795 . 60000 . 10.1186/1471-2164-2-8 . free .
2. Web site: Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3.
3. Web site: Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3.