NPLOC4 explained

Nuclear protein localization protein 4 homolog is a protein that in humans is encoded by the NPLOC4 gene.^{[1] [2] [3]}

Interactions

NPLOC4 has been shown to interact with UFD1L.^[4]

Further reading

• McConnell E, Lass A, Wójcik C . Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation . Biochem. Biophys. Res. Commun. . 355 . 4 . 1087–90 . 2007 . 17331469 . 10.1016/j.bbrc.2007.02.077 .
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 7 . 2 . 143–50 . 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .

Notes and References

1. Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G . Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L) . Gene . 275 . 1 . 39–46 . Sep 2001 . 11574150 . 10.1016/S0378-1119(01)00649-7 .
2. Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G . A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways . EMBO J . 19 . 10 . 2181–92 . Jun 2000 . 10811609 . 384367 . 10.1093/emboj/19.10.2181 .
3. Web site: Entrez Gene: NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae).
4. Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C . Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD . Exp. Cell Res. . 314 . 14 . 2715–23 . Aug 2008 . 18586029 . 10.1016/j.yexcr.2008.06.008 .