NPDC1 explained
Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene.[1] [2]
Interactions
NPDC1 has been shown to interact with E2F1.[3]
Further reading
- Dupont E, Sansal I, Toru D, Evrard C, Rouget P . [Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors] . C. R. Séances Soc. Biol. Fil. . 191 . 1 . 95–104 . 1997 . 9181131 .
- Galiana E, Vernier P, Dupont E, Evrard C, Rouget P . Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation . Proc. Natl. Acad. Sci. U.S.A. . 92 . 5 . 1560–4 . 1995 . 7878019 . 42559 . 10.1073/pnas.92.5.1560 . 1995PNAS...92.1560G . free .
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Iwasaki K, Toyonaga R . The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission . EMBO J. . 19 . 17 . 4806–16 . 2000 . 10970871 . 302062 . 10.1093/emboj/19.17.4806 .
- Sansal I, Dupont E, Toru D, Evrard C, Rouget P . NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity . Oncogene . 19 . 43 . 5000–9 . 2000 . 11042687 . 10.1038/sj.onc.1203843 . free .
- Spencer ML, Theodosiou M, Noonan DJ . NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif . J. Biol. Chem. . 279 . 35 . 37069–78 . 2004 . 15229225 . 10.1074/jbc.M402507200 . free .
- Evrard C, Caron S, Rouget P . Functional analysis of the NPDC-1 gene . Gene . 343 . 1 . 153–63 . 2004 . 15563841 . 10.1016/j.gene.2004.08.020 .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
Notes and References
- Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F . Characterization and tissue expression of a novel human gene npdc1 . Gene . 264 . 1 . 37–44 . March 2001 . 11245976 . 10.1016/S0378-1119(01)00324-9 .
- Web site: Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1.
- Sansal I, Dupont E, Toru D, Evrard C, Rouget P . NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity . Oncogene . 19 . 43 . 5000–9 . October 2000 . 11042687 . 10.1038/sj.onc.1203843 . free .