NPAT (gene) explained

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.^{[1] [2]}

Interactions

NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase^[3] and POU2F1.^[3]

See also

• ATM serine/threonine kinase, also located at 11p22.3, so the location is "ATM locus"

Further reading

• Imai T, Yamauchi M, Seki N, Sugawara T, Saito T, Matsuda Y, Ito H, Nagase T, Nomura N, Hori T . Identification and characterization of a new gene physically linked to the ATM gene . Genome Research . 6 . 5 . 439–47 . May 1996 . 8743993 . 10.1101/gr.6.5.439 . free .
• Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA, Taylor AM . Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia . Human Molecular Genetics . 5 . 1 . 145–9 . Jan 1996 . 8789452 . 10.1093/hmg/5.1.145 . free .
• Byrd PJ, Cooper PR, Stankovic T, Kullar HS, Watts GD, Robinson PJ, Taylor MR . A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies . Human Molecular Genetics . 5 . 11 . 1785–91 . Nov 1996 . 8923007 . 10.1093/hmg/5.11.1785 . free .
• Zhao J, Dynlacht B, Imai T, Hori T, Harlow E . Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry . Genes & Development . 12 . 4 . 456–61 . Feb 1998 . 9472014 . 316526 . 10.1101/gad.12.4.456 .
• Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E . NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription . Genes & Development . 14 . 18 . 2283–97 . Sep 2000 . 10995386 . 316937 . 10.1101/gad.827700 .
• Sagara M, Takeda E, Nishiyama A, Utsumi S, Toyama Y, Yuasa S, Ninomiya Y, Imai T . Characterization of functional regions for nuclear localization of NPAT . Journal of Biochemistry . 132 . 6 . 875–9 . Dec 2002 . 12473189 . 10.1093/oxfordjournals.jbchem.a003300.
• Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J . NPAT expression is regulated by E2F and is essential for cell cycle progression . Molecular and Cellular Biology . 23 . 8 . 2821–33 . Apr 2003 . 12665581 . 152552 . 10.1128/MCB.23.8.2821-2833.2003 .
• Wei Y, Jin J, Harper JW . The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain . Molecular and Cellular Biology . 23 . 10 . 3669–80 . May 2003 . 12724424 . 164767 . 10.1128/MCB.23.10.3669-3680.2003 .
• Zheng L, Roeder RG, Luo Y . S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component . Cell . 114 . 2 . 255–66 . Jul 2003 . 12887926 . 10.1016/S0092-8674(03)00552-X . 5543647 . free .
• Ye X, Wei Y, Nalepa G, Harper JW . The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells . Molecular and Cellular Biology . 23 . 23 . 8586–600 . Dec 2003 . 14612403 . 262656 . 10.1128/MCB.23.23.8586-8600.2003 .
• Wang A, Ikura T, Eto K, Ota MS . Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry . Biochemical and Biophysical Research Communications . 325 . 4 . 1509–16 . Dec 2004 . 15555599 . 10.1016/j.bbrc.2004.10.198 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P . Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B . European Journal of Cancer . 43 . 8 . 1328–35 . May 2007 . 17449237 . 10.1016/j.ejca.2007.02.005 .
• Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS . The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes . Cancer Research . 67 . 21 . 10334–42 . Nov 2007 . 17974976 . 10.1158/0008-5472.CAN-07-1560 . free .

Notes and References

1. Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T . The structure and organization of the human NPAT gene . Genomics . 42 . 3 . 388–92 . Jun 1997 . 9205109 . 10.1006/geno.1997.4769 .
2. Web site: Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus.
3. Zheng L, Roeder RG, Luo Y . S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component . Cell . 114 . 2 . 255–66 . Jul 2003 . 12887926 . 10.1016/S0092-8674(03)00552-X . 5543647 . free .