NOSH-aspirin explained

NOSH-Aspirin is a category of new hybrids of acetylsalicylic acid, bearing both nitric oxide (NO)- and hydrogen sulfide (H₂S)- releasing areas. Preliminary studies have found that four NOSH variants, evaluated in eleven different human cancer cell lines, were effective in inhibiting the growth of these cell lines. NOSH-1 was also devoid of any cellular toxicity, and was comparable to aspirin in its anti-inflammatory properties.^{[1] [2]}

Notes and References

1. Chattopadhyay M, Kodela R, Olson KR, Kashfi K . NOSH-aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model . Biochem. Biophys. Res. Commun. . 419 . 3 . 523–8 . March 2012 . 22366248 . 10.1016/j.bbrc.2012.02.051 .
2. Kodela. Ravinder . Chattopadhyay, Mitali . Kashfi, Khosrow. NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals. ACS Medicinal Chemistry Letters. 8 March 2012. 3. 3. 257–262. 10.1021/ml300002m. 3423220. 22916316.