NOL5A explained

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.^{[1] [2]}

Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them have not been determined.

Further reading

• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . Lyon CE . Fox AH . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Watkins NJ, Dickmanns A, Lührmann R . Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP . Mol. Cell. Biol. . 22 . 23 . 8342–52 . 2003 . 12417735 . 10.1128/MCB.22.23.8342-8352.2002 . 134055 .
• Scherl A . Functional proteomic analysis of human nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 . Couté Y . Déon C . Callé . A . Kindbeiter . K . Sanchez . JC . Greco . A . Hochstrasser . D . Diaz . JJ .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Hayano T . Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome . J. Biol. Chem. . 278 . 36 . 34309–19 . 2003 . 12777385 . 10.1074/jbc.M304304200 . Yanagida M . Yamauchi Y . Shinkawa . T . Isobe . T . Takahashi . N . free.
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Hassel S . Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry . Proteomics . 4 . 5 . 1346–58 . 2004 . 15188402 . 10.1002/pmic.200300770 . Eichner A . Yakymovych M . Hellman . Ulf . Knaus . Petra . Souchelnytskyi . Serhiy . 6773754 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Watkins NJ . Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex . Mol. Cell . 16 . 5 . 789–98 . 2005 . 15574333 . 10.1016/j.molcel.2004.11.012 . Lemm I . Ingelfinger D . Schneider . Claudia . Hoßbach . Markus . Urlaub . Henning . Lührmann . Reinhard . 11858/00-001M-0000-0012-EB89-8 . free .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . Lam YW . Leung AK . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Nousiainen M . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . Silljé HH . Sauer G . Nigg . EA . Körner . R . 2006PNAS..103.5391N . free .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . Blagoev B . Gnad F . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.

Notes and References

1. Gautier T, Berges T, Tollervey D, Hurt E . Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis . Mol Cell Biol . 17 . 12 . 7088–98 . Dec 1997 . 9372940 . 232565 . 10.1128/MCB.17.12.7088.
2. Web site: Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat).