NOMO1 explained

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene.^{[1] [2] [3]}

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).

Further reading

• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Pope SN, Lee IR . Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin . J. Steroid Biochem. Mol. Biol. . 94 . 1–3 . 203–8 . 2005 . 15862967 . 10.1016/j.jsbmb.2005.01.007 . 9746088 .
• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16 . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . free .
• Colland F, Jacq X, Trouplin V, etal . Functional Proteomics Mapping of a Human Signaling Pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Loftus BJ, Kim UJ, Sneddon VP, etal . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . 1999 . 10493829 . 10.1006/geno.1999.5927 .
• van Soest S, Swart J, Tijmes N, etal . A Locus for Autosomal Recessive Pseudoxanthoma Elasticum, with Penetrance of Vascular Symptoms in Carriers, Maps to Chromosome 16p13.1 . Genome Res. . 7 . 8 . 830–4 . 1997 . 9267806 . 10.1101/gr.7.8.830. 310666 .
• Matoba R, Okubo K, Hori N, etal . The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression . Gene . 146 . 2 . 199–207 . 1994 . 8076819 . 10.1016/0378-1119(94)90293-3 .

Notes and References

1. Templeton NS, Rodgers LA, Levy AT, Ting KL, Krutzsch HC, Liotta LA, Stetler-Stevenson WG . Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family . Genomics . 12 . 1 . 175–6 . Mar 1992 . 1310294 . 10.1016/0888-7543(92)90425-R .
2. Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C . Nicalin and its binding partner Nomo are novel Nodal signaling antagonists . EMBO J . 23 . 15 . 3041–50 . Aug 2004 . 15257293 . 514924 . 10.1038/sj.emboj.7600307 .
3. Web site: Entrez Gene: NOMO1 NODAL modulator 1.