NOM1 explained

Nucleolar protein with MIF4G domain 1 is a protein that in humans is encoded by the NOM1 gene.^[1]

Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases.^{[2] [1]}

Further reading

• Heus HC, Hing A, van Baren MJ, Joosse M, Breedveld GJ, Wang JC, Burgess A, Donnis-Keller H, Berglund C, Zguricas J, Scherer SW, Rommens JM, Oostra BA, Heutink P . A physical and transcriptional map of the preaxial polydactyly locus on chromosome 7q36 . Genomics . 57 . 3 . 342–351 . May 1999 . 10329000 . 10.1006/geno.1999.5796 .
• Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF . Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia . Gene . 347 . 1 . 137–145 . February 2005 . 15715967 . 10.1016/j.gene.2004.12.027 .
• Gunawardena SR, Ruis BL, Meyer JA, Kapoor M, Conklin KF . NOM1 targets protein phosphatase I to the nucleolus . The Journal of Biological Chemistry . 283 . 1 . 398–404 . January 2008 . 17965019 . 10.1074/jbc.M706708200 . free .
• Alexandrov A, Colognori D, Steitz JA . Human eIF4AIII interacts with an eIF4G-like partner, NOM1, revealing an evolutionarily conserved function outside the exon junction complex . Genes & Development . 25 . 10 . 1078–1090 . May 2011 . 21576267 . 3093123 . 10.1101/gad.2045411 .

Notes and References

1. Web site: Entrez Gene: Nucleolar protein with MIF4G domain 1. 2011-09-27.
2. Simmons HM, Ruis BL, Kapoor M, Hudacek AW, Conklin KF . Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia . Gene . 347 . 1 . 137–145 . February 2005 . 15715967 . 10.1016/j.gene.2004.12.027 .