NNC 38-1049 explained

NNC 38-1049 is a histamine antagonist selective for the H3 subtype. It has anorectic effects in animal studies and is being researched as a potential treatment for obesity.[1] [2]

Notes and References

  1. Malmlöf K, Zaragoza F, Golozoubova V, etal . Influence of a selective histamine H3 receptor antagonist on hypothalamic neural activity, food intake and body weight . Int J Obes (Lond) . 29 . 12 . 1402–12 . December 2005 . 16151415 . 10.1038/sj.ijo.0803036. free .
  2. Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K . Dec 2006 . Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides . Obesity (Silver Spring) . 14 . 12. 2154–62 . 17189541 . 10.1038/oby.2006.252 . free .

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