NM-2201 explained

NM-2201 (also known as CBL-2201 and NA-5F-PIC[1]) is an indole-based synthetic cannabinoid that presumably has similar properties to the closely related 5F-PB-22 and NNE1, which are both full agonists and unselectively bind to CB1 and CB2 receptors with low nanomolar affinity.[2] [3] [4] [5]

Pharmacology

NM-2201 acts as a full agonist with a binding affinity of 0.332 nM at CB1 and 0.732 nM at CB2 cannabinoid receptors.[6] It has been linked to serious adverse events in users.[7]

Legal status

NM-2201 is specifically banned in Sweden,[8] Germany (Anlage II),[9] and Japan[10] but is also controlled in many other jurisdictions under analogue laws.

On May 30, 2018 the United States Drug Enforcement Administration, Department of Justice published a notice of intent to place NM-2201 and 4 other synthetic cannabinoids in schedule I of the Controlled Substances Act. This notice went into effect on June 29, 2018.

Use

NM-2201 was linked to an incident in December 2015 where 25-30 people in Ocala, FL were taken to hospitals after experiencing seizures.[11]

See also

Notes and References

  1. Pulver B, Fischmann S, Gallegos A, Christie R . EMCDDA framework and practical guidance for naming synthetic cannabinoids . Drug Testing and Analysis . 15 . 3 . 255–276 . March 2023 . 36346325 . 10.1002/dta.3403 .
  2. Kondrasenko AA, Goncharov EV, Dugaev KP, Rubaylo AI . CBL-2201. Report on a new designer drug: Napht-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate . Forensic Science International . 257 . 209–213 . December 2015 . 26386336 . 10.1016/j.forsciint.2015.08.023 .
  3. Web site: NM-2201 . Cayman Chemical . 9 July 2015.
  4. Namera A, Kawamura M, Nakamoto A, Saito T, Nagao M . Comprehensive review of the detection methods for synthetic cannabinoids and cathinones . Forensic Toxicology . 33 . 2 . 175–194 . 2015 . 26257831 . 4525208 . 10.1007/s11419-015-0270-0 .
  5. Shevyrin V, Melkozerov V, Nevero A, Eltsov O, Baranovsky A, Shafran Y . Synthetic cannabinoids as designer drugs: new representatives of indol-3-carboxylates series and indazole-3-carboxylates as novel group of cannabinoids. Identification and analytical data . Forensic Science International . 244 . 263–75 . November 2014 . 25305529 . 10.1016/j.forsciint.2014.09.013 .
  6. Hess C, Schoeder CT, Pillaiyar T, Madea B, Müller CE . Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice . Forensic Toxicology . 34 . 2 . 329–343 . 2016 . 27429655 . 4929166 . 10.1007/s11419-016-0320-2 .
  7. Samra K, Boon IS, Packer G, Jacob S . black mamba . BMJ Case Reports . 2017 . bcr–2016–218431 . April 2017 . 28433979 . 5534782 . 10.1136/bcr-2016-218431 .
  8. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . Cannabinoids are proposed to be classified as a health hazard . Folkhälsomyndigheten (The Public Health Authority) . 9 July 2015 . sv.
  9. Web site: Gesetz über den Verkehr mit Betäubungsmitteln Anlage II . Law on the Traffic in Narcotics Annex II . www.gesetze-im-internet.de. Bundesministerium der Justiz und für Verbraucherschutz. de. 24 October 2016.
  10. Diao X, Carlier J, Zhu M, Pang S, Kronstrand R, Scheidweiler KB, Huestis MA . In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201) . Forensic Toxicology . 35 . 1 . 20–32 . January 2017 . 28286577 . 5342258 . 10.1007/s11419-016-0326-9 .
  11. Web site: 2018 - Temporary Placement of NM2201, 5F-AB-PINACA, 4-CN-CUMYL-BUTINACA, MMB-CHMICA and 5F-CUMYL-P7AICA Into Schedule I. www.deadiversion.usdoj.gov. en-US. 2018-06-15.

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