NLRP8 explained

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.^{[1] [2]} It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

Further reading

• Enjuanes A, Benavente Y, Bosch F, etal . Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. . Cancer Res. . 68 . 24 . 10178–86 . 2008 . 19074885 . 10.1158/0008-5472.CAN-08-2221 . free .
• Inohara N, Nuñez G . NODs: intracellular proteins involved in inflammation and apoptosis. . Nat. Rev. Immunol. . 3 . 5 . 371–82 . 2003 . 12766759 . 10.1038/nri1086 . 8088987 .
• Tschopp J, Martinon F, Burns K . NALPs: a novel protein family involved in inflammation. . Nat. Rev. Mol. Cell Biol. . 4 . 2 . 95–104 . 2003 . 12563287 . 10.1038/nrm1019 . 31417018 .

Notes and References

1. Ponsuksili S, Brunner RM, Goldammer T, etal . Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos . Biol. Reprod. . 74 . 3 . 577–84 . March 2006 . 16339045 . 10.1095/biolreprod.105.045096 . 2784688 .
2. Tian X, Pascal G, Monget P . Evolution and functional divergence of NLRP genes in mammalian reproductive systems . BMC Evol. Biol. . 9 . 202 . 2009 . 1 . 19682372 . 2735741 . 10.1186/1471-2148-9-202 . 2009BMCEE...9..202T . free .