NLRP7 explained

NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.^{[1] [2] [3]}

Function

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.

Further reading

• Inohara N, Nuñez G . NODs: intracellular proteins involved in inflammation and apoptosis. . Nat. Rev. Immunol. . 3 . 5 . 371–82 . 2003 . 12766759 . 10.1038/nri1086 . 8088987 .
• Moglabey YB, Kircheisen R, Seoud M, etal . Genetic mapping of a maternal locus responsible for familial hydatidiform moles. . Hum. Mol. Genet. . 8 . 4 . 667–71 . 1999 . 10072436 . 10.1093/hmg/8.4.667 . free .
• Grenier JM, Wang L, Manji GA, etal . Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. . FEBS Lett. . 530 . 1–3 . 73–8 . 2002 . 12387869 . 10.1016/S0014-5793(02)03416-6 . 25023390 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Okada K, Hirota E, Mizutani Y, etal . Oncogenic role of NALP7 in testicular seminomas. . Cancer Sci. . 95 . 12 . 949–54 . 2005 . 15596043 . 10.1111/j.1349-7006.2004.tb03182.x . 13403889 . free . 11158205 .
• Kinoshita T, Wang Y, Hasegawa M, etal . PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. . J. Biol. Chem. . 280 . 23 . 21720–5 . 2005 . 15817483 . 10.1074/jbc.M410057200 . free . 2297/2649 . free .
• Murdoch S, Djuric U, Mazhar B, etal . Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. . Nat. Genet. . 38 . 3 . 300–2 . 2006 . 16462743 . 10.1038/ng1740 . 28580007 .
• Bestor TH, Bourc'his D . Genetics and epigenetics of hydatidiform moles. . Nat. Genet. . 38 . 3 . 274–6 . 2006 . 16501554 . 10.1038/ng0306-274 . 22981053 .
• Djuric U, El-Maarri O, Lamb B, etal . Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. . Hum. Genet. . 120 . 3 . 390–5 . 2007 . 16874523 . 10.1007/s00439-006-0192-3 . 10117000 .
• Qian J, Deveault C, Bagga R, etal . Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations. . Hum. Mutat. . 28 . 7 . 741 . 2007 . 17579354 . 10.1002/humu.9498 . 43136262 . free .

Notes and References

1. Tschopp J, Martinon F, Burns K . NALPs: a novel protein family involved in inflammation . Nat Rev Mol Cell Biol . 4 . 2 . 95–104 . Feb 2003 . 12563287 . 10.1038/nrm1019 . 31417018 .
2. Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J . PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing . J Biol Chem . 277 . 33 . 29874–80 . Aug 2002 . 12019269 . 10.1074/jbc.M203915200 . free .
3. Web site: Entrez Gene: NLRP7 NLR family, pyrin domain containing 7.