NLRP14 explained

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.^[1] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.^[2]

Further reading

• Enjuanes A, Benavente Y, Bosch F, etal . Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. . Cancer Res. . 68 . 24 . 10178–86 . 2008 . 19074885 . 10.1158/0008-5472.CAN-08-2221 . free .
• Inohara N, Nuñez G . NODs: intracellular proteins involved in inflammation and apoptosis. . Nat. Rev. Immunol. . 3 . 5 . 371–82 . 2003 . 12766759 . 10.1038/nri1086 . 8088987 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)

Notes and References

1. Tschopp J, Martinon F, Burns K . NALPs: a novel protein family involved in inflammation . Nat. Rev. Mol. Cell Biol. . 4 . 2 . 95–104 . February 2003 . 12563287 . 10.1038/nrm1019 . 31417018 .
2. Westerveld GH, Korver CM, van Pelt AM, etal . Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure . Hum. Reprod. . 21 . 12 . 3178–84 . December 2006 . 16931801 . 10.1093/humrep/del293 . free .