NLRP10 explained

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP10 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.^{[1] [2]}

Further reading

• Wang Y, Hasegawa M, Imamura R, etal . PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. . Int. Immunol. . 16 . 6 . 777–86 . 2004 . 15096476 . 10.1093/intimm/dxh081 . free . 2297/15871 . free .
• Kinoshita T, Wang Y, Hasegawa M, etal . PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. . J. Biol. Chem. . 280 . 23 . 21720–5 . 2005 . 15817483 . 10.1074/jbc.M410057200 . free . 2297/2649 . free .
• Zheng D, Mohapatra G, Kern L, etal . Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation . Nat. Immunology . 24 . 4 . 585–594 . 2023 . 36941399 . 10.1038/s41590-023-01450-z . 257639248 .
• Inohara N, Nuñez G . NODs: intracellular proteins involved in inflammation and apoptosis. . Nat. Rev. Immunol. . 3 . 5 . 371–82 . 2003 . 12766759 . 10.1038/nri1086 . 8088987 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . free .
• Tschopp J, Martinon F, Burns K . NALPs: a novel protein family involved in inflammation. . Nat. Rev. Mol. Cell Biol. . 4 . 2 . 95–104 . 2003 . 12563287 . 10.1038/nrm1019 . 31417018 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Ha HJ, Kim DS, Hahn Y . A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence. . Biochem. Genet. . 47 . 9–10 . 665–70 . 2009 . 19544093 . 10.1007/s10528-009-9262-2 . 31002187 .
• Ha HJ, Kim DS, Hahn Y . A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence. . Biochem. Genet. . 47 . 9–10 . 665–70 . 2009 . 19544093 . 10.1007/s10528-009-9262-2 . 31002187 .

Notes and References

1. Wang Y, Hasegawa M, Imamura R, etal . PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1 . Int. Immunol. . 16 . 6 . 777–86 . June 2004 . 15096476 . 10.1093/intimm/dxh081 . free . 2297/15871 . free .
2. Imamura R, Wang Y, Kinoshita T, etal . Anti-inflammatory activity of PYNOD and its mechanism in humans and mice . J. Immunol. . 184 . 10 . 5874–84 . May 2010 . 20393137 . 10.4049/jimmunol.0900779 . free .