NKX2-3 explained

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.^{[1] [2] [3]}

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.^[3]

Further reading

• Harvey RP . NK-2 homeobox genes and heart development. . Dev. Biol. . 178 . 2 . 203–16 . 1996 . 8812123 . 10.1006/dbio.1996.0212 . free .
• Pabst O, Zweigerdt R, Arnold HH . Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen. . Development . 126 . 10 . 2215–25 . 1999 . 10.1242/dev.126.10.2215 . 10207146 .
• Phiel CJ . Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues . J. Biol. Chem. . 276 . 37 . 34637–50 . 2001 . 11457859 . 10.1074/jbc.M105826200 . vanc. Gabbeta V . Parsons LM . 3 . Rothblat . D . Harvey . RP . McHugh . KM . free.
• Biben C, Wang CC, Harvey RP . NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis . Int. J. Dev. Biol. . 46 . 4 . 415–22 . 2003 . 12141427 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . vanc. Earthrowl ME . Grafham DV . 3 . Rubenfield . M. . French . L. . Steward . C. A. . Sims . S. K. . Jones . M. C. . Searle . S. . 2004Natur.429..375D . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R . Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain . Neuron . 8 . 2 . 241–55 . Mar 1992 . 1346742 . 10.1016/0896-6273(92)90291-K . 22766848 .
2. Pabst O, Schneider A, Brand T, Arnold HH . The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development . Dev Dyn . 209 . 1 . 29–35 . Jul 1997 . 9142493 . 10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z . free .
3. Web site: Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila).