NKTR explained

NK-tumor recognition protein is a protein that in humans is encoded by the NKTR gene.^{[1] [2] [3]}

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.

Further reading

• Frey JL . Mechanism of target cell recognition by natural killer cells: characterization of a novel triggering molecule restricted to CD3- large granular lymphocytes . J. Exp. Med. . 174 . 6 . 1527–1536 . 1992 . 1720812 . 10.1084/jem.174.6.1527 . 2119033 . vanc. Bino T . Kantor RR . 3 . Segal . DM . Giardina . SL . Roder . J . Anderson . S . Ortaldo . JR .
• Rinfret A, Anderson SK . IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism . Mol. Immunol. . 30 . 14 . 1307–1313 . 1993 . 8413330 . 10.1016/0161-5890(93)90047-F .
• Anderson SK . A cyclophilin-related protein involved in the function of natural killer cells . Proc. Natl. Acad. Sci. U.S.A. . 90 . 2 . 542–546 . 1993 . 8421688 . 10.1073/pnas.90.2.542 . 45699 . vanc. Gallinger S . Roder J . 3 . Frey . J . Young . HA . Ortaldo . JR . 1993PNAS...90..542A . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Sakashita E . Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo . Mol. Cell. Biol. . 24 . 3 . 1174–1187 . 2004 . 14729963 . 10.1128/MCB.24.3.1174-1187.2004 . 321435 . vanc. Tatsumi S . Werner D . 3 . Endo . H. . Mayeda . A. .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• Davis TL, Walker JR, Campagna-Slater V, etal . Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases . PLOS Biol. . 8 . 7 . e1000439 . 2010 . 20676357 . 10.1371/journal.pbio.1000439 . 2911226 . free .

Notes and References

1. Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK . Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9 . Genomics . 16 . 2 . 548–549 . Jul 1993 . 8314596 . 10.1006/geno.1993.1229 .
2. Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J . Expression of the NK-TR gene is required for NK-like activity in human T cells . J Immunol . 152 . 6 . 2669–74 . May 1994 . 10.4049/jimmunol.152.6.2669 . 8144875 . 20265645 . free .
3. Web site: Entrez Gene: NKTR natural killer-tumor recognition sequence.