Nidogen-2 Explained

Nidogen-2, also known as osteonidogen, is a basal lamina protein of the nidogen family. It was the second nidogen to be described after nidogen-1 (entactin). Both play key roles during late embryonic development.^[1] In humans it is encoded by the NID2 gene.^{[2] [3]}

Further reading

• Ulazzi L, Sabbioni S, Miotto E, Veronese A, Angusti A, Gafà R, Manfredini S, Farinati F, Sasaki T, Lanza G, Negrini M . Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer . Molecular Cancer . 6 . 1 . 17 . 2007 . 17328794 . 1831485 . 10.1186/1476-4598-6-17 . free .
• Nischt R, Schmidt C, Mirancea N, Baranowsky A, Mokkapati S, Smyth N, Woenne EC, Stark HJ, Boukamp P, Breitkreutz D . Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture . The Journal of Investigative Dermatology . 127 . 3 . 545–54 . Mar 2007 . 17008882 . 10.1038/sj.jid.5700562 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Miosge N, Sasaki T, Timpl R . Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice . Matrix Biology . 21 . 7 . 611–21 . Nov 2002 . 12475645 . 10.1016/S0945-053X(02)00070-7 .
• Tu H, Sasaki T, Snellman A, Göhring W, Pirilä P, Timpl R, Pihlajaniemi T . The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin . The Journal of Biological Chemistry . 277 . 25 . 23092–9 . Jun 2002 . 11956183 . 10.1074/jbc.M107583200 . free .
• Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R . Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins . Journal of Molecular Biology . 314 . 4 . 751–63 . Dec 2001 . 11733994 . 10.1006/jmbi.2001.5176 .
• Sasaki T, Göhring W, Miosge N, Abrams WR, Rosenbloom J, Timpl R . Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins . FEBS Letters . 460 . 2 . 280–4 . Oct 1999 . 10544250 . 10.1016/S0014-5793(99)01362-9 . 25139630 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R . Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development . The Histochemical Journal . 33 . 9–10 . 523–30 . 2002 . 12005023 . 10.1023/A:1014995523521 . 818451 .
2. Kohfeldt E, Sasaki T, Göhring W, Timpl R . Nidogen-2: a new basement membrane protein with diverse binding properties . Journal of Molecular Biology . 282 . 1 . 99–109 . Sep 1998 . 9733643 . 10.1006/jmbi.1998.2004 .
3. Web site: Entrez Gene: NID2 nidogen 2 (osteonidogen).