NHP2L1 explained

NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene.^{[1] [2]}

Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.^[2]

Interactions

SNU13 has been shown to interact with RAD17.^[3]

Further reading

• Nottrott S, Hartmuth K, Fabrizio P, Urlaub H, Vidovic I, Ficner R, Lührmann R . Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA . The EMBO Journal . 18 . 21 . 6119–33 . Nov 1999 . 10545122 . 1171676 . 10.1093/emboj/18.21.6119 .
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . Dec 1999 . 10591208 . 10.1038/990031 . 1999Natur.402..489D . free .
• Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB . HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation . The Journal of Biological Chemistry . 274 . 51 . 36544–9 . Dec 1999 . 10593953 . 10.1074/jbc.274.51.36544 . free .
• Vidovic I, Nottrott S, Hartmuth K, Lührmann R, Ficner R . Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment . Molecular Cell . 6 . 6 . 1331–42 . Dec 2000 . 11163207 . 10.1016/S1097-2765(00)00131-3 . free . 11858/00-001M-0000-0012-F75C-F . free .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Current Biology . 12 . 1 . 1–11 . Jan 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . free . 2002CBio...12....1A .
• Leung AK, Lamond AI . In vivo analysis of NHPX reveals a novel nucleolar localization pathway involving a transient accumulation in splicing speckles . The Journal of Cell Biology . 157 . 4 . 615–29 . May 2002 . 12011111 . 2173864 . 10.1083/jcb.200201120 .
• Watkins NJ, Dickmanns A, Lührmann R . Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP . Molecular and Cellular Biology . 22 . 23 . 8342–52 . Dec 2002 . 12417735 . 134055 . 10.1128/MCB.22.23.8342-8352.2002 .
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ . Functional proteomic analysis of human nucleolus . Molecular Biology of the Cell . 13 . 11 . 4100–9 . Nov 2002 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 .
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I . A genome annotation-driven approach to cloning the human ORFeome . Genome Biology . 5 . 10 . R84 . 2005 . 15461802 . 545604 . 10.1186/gb-2004-5-10-r84 . free .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . Jan 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y . Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2 . Cytogenetics and Cell Genetics . 72 . 2–3 . 191–3 . Jan 1997 . 8978773 . 10.1159/000134186 .
2. Web site: Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae).
3. Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB . HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation . The Journal of Biological Chemistry . 274 . 51 . 36544–9 . Dec 1999 . 10593953 . 10.1074/jbc.274.51.36544 . free .