NHLH1 explained

Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.^[1]

The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM]

Further reading

• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . vanc. Venkatesan K . Hao T . 3 . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Manetopoulos C . The LIM-only protein LMO4 modulates the transcriptional activity of HEN1 . Biochem. Biophys. Res. Commun. . 307 . 4 . 891–9 . 2003 . 12878195 . 10.1016/S0006-291X(03)01298-1 . vanc. Hansson A . Karlsson J . 3 . Jönsson . Jan-Ingvar . Axelson . Håkan .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Bao J, Talmage DA, Role LW, Gautier J . Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins . Development . 127 . 2 . 425–35 . 2000 . 10.1242/dev.127.2.425 . 10603358 .
• Begley CG . Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system . Proc. Natl. Acad. Sci. U.S.A. . 89 . 1 . 38–42 . 1992 . 1729708 . 10.1073/pnas.89.1.38 . 48170 . vanc. Lipkowitz S . Göbel V . 3 . Mahon . KA . Bertness . V . Green . AR . Gough . NM . Kirsch . IR . 1992PNAS...89...38B . free .
• Brown L . HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human neuroblastoma . Proc. Natl. Acad. Sci. U.S.A. . 89 . 18 . 8492–6 . 1992 . 1528853 . 10.1073/pnas.89.18.8492 . 49946 . vanc. Espinosa R . Le Beau MM . 3 . Siciliano . MJ . Baer . R . 1992PNAS...89.8492B . free .
• Lipkowitz S . A comparative structural characterization of the human NSCL-1 and NSCL-2 genes. Two basic helix-loop-helix genes expressed in the developing nervous system . J. Biol. Chem. . 267 . 29 . 21065–71 . 1992 . 1328219 . vanc. Göbel V . Varterasian ML . 3 . Nakahara . K . Tchorz . K . Kirsch . IR . 10.1016/S0021-9258(19)36798-5 . free.

Notes and References

1. Web site: Entrez Gene: NHLH1 nescient helix loop helix 1.