NFX1 explained

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.^{[1] [2] [3]}

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.^[4]

References

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lorick KL, Jensen JP, Fang S, etal . RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination . Proc. Natl. Acad. Sci. U.S.A. . 96 . 20 . 11364–9 . 1999 . 10500182 . 10.1073/pnas.96.20.11364 . 18039 . 1999PNAS...9611364L . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Saito K, Fujiwara T, Katahira J, etal . TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD . Biochem. Biophys. Res. Commun. . 321 . 2 . 291–7 . 2004 . 15358174 . 10.1016/j.bbrc.2004.06.140 .
• Gewin L, Myers H, Kiyono T, Galloway DA . Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex . Genes Dev. . 18 . 18 . 2269–82 . 2004 . 15371341 . 10.1101/gad.1214704 . 517520 .
• Katzenellenbogen RA, Egelkrout EM, Vliet-Gregg P, etal . NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells . J. Virol. . 81 . 8 . 3786–96 . 2007 . 17267499 . 10.1128/JVI.02007-06 . 1866132 .

Notes and References

1. Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ . A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor . J Exp Med . 180 . 5 . 1763–74 . Dec 1994 . 7964459 . 2191754 . 10.1084/jem.180.5.1763 .
2. Hume CR, Lee JS . Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors . Hum Immunol . 26 . 4 . 288–309 . Jan 1990 . 2511169 . 10.1016/0198-8859(89)90007-4 .
3. Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ . Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression . Immunology . 106 . 2 . 173–81 . June 2002 . 12047746 . 1782705 . 10.1046/j.1365-2567.2002.01416.x .
4. Web site: Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1.