NFKBIL1 explained

NF-kappa-B inhibitor-like protein 1 is a protein that in humans is encoded by the NFKBIL1 gene.^{[1] [2]}

Function

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function is unclear. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6.^[2]

Further reading

• Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J . Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment . Nature Genetics . 3 . 2 . 137–45 . Feb 1993 . 8499947 . 10.1038/ng0293-137 . 33041319 .
• Shiina T, Tamiya G, Oka A, Yamagata T, Yamagata N, Kikkawa E, Goto K, Mizuki N, Watanabe K, Fukuzumi Y, Taguchi S, Sugawara C, Ono A, Chen L, Yamazaki M, Tashiro H, Ando A, Ikemura T, Kimura M, Inoko H . Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region . Genomics . 47 . 3 . 372–82 . Feb 1998 . 9480751 . 10.1006/geno.1997.5114 .
• Neville MJ, Campbell RD . A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC . Journal of Immunology . 162 . 8 . 4745–54 . Apr 1999 . 10.4049/jimmunol.162.8.4745 . 10202016 .
• Allcock RJ, Christiansen FT, Price P . The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15 . Immunogenetics . 49 . 7–8 . 660–5 . Jul 1999 . 10369924 . 10.1007/s002510050662 . 32440895 .
• Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H . Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis . American Journal of Human Genetics . 72 . 2 . 303–12 . Feb 2003 . 12509789 . 379224 . 10.1086/346067 .
• Lin CH, Cho CL, Tsai WC, Ou TT, Wu CC, Yen JH, Liu HW . Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis . Immunology Letters . 105 . 2 . 193–7 . Jun 2006 . 16644022 . 10.1016/j.imlet.2006.03.003 .
• Glas J, Török HP, Tonenchi L, Müller-Myhsok B, Mussack T, Wetzke M, Klein W, Epplen JT, Griga T, Schiemann U, Lohse P, Seiderer J, Schnitzler F, Brand S, Ochsenkühn T, Folwaczny M, Folwaczny C . Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes . Inflammatory Bowel Diseases . 12 . 7 . 606–11 . Jul 2006 . 16804398 . 10.1097/01.ibd.0000225346.23765.6b . 25535173 . free .
• Koch W, Hoppmann P, Michou E, Jung V, Pfeufer A, Mueller JC, Gieger C, Wichmann HE, Meitinger T, Schömig A, Kastrati A . Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans . Human Molecular Genetics . 16 . 15 . 1821–7 . Aug 2007 . 17517687 . 10.1093/hmg/ddm130 . free .
• Ramasawmy R, Faé KC, Cunha-Neto E, Borba SC, Ianni B, Mady C, Goldberg AC, Kalil J . Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals . Molecular Immunology . 45 . 1 . 283–8 . Jan 2008 . 17544510 . 10.1016/j.molimm.2007.04.015 .
• Kariz S, Milutinović A, Bregar D, Terzić I, Terzić R, Lovrecić L, Herova M, Hruskovicova H, Peterlin B, Petrovic D, Zorc-Pleskovic R . The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes . Collegium Antropologicum . 31 . 2 . 503–7 . Jun 2007 . 17847930 .

Notes and References

1. Albertella MR, Campbell RD . Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins . Human Molecular Genetics . 3 . 5 . 793–9 . May 1994 . 8081366 . 10.1093/hmg/3.5.793 .
2. Web site: Entrez Gene: NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1.